Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390

The inhibition of ataxia-telangiectasia mutated (ATM) has been shown to chemo- and radio-sensitize human glioma cells in vitro and therefore might provide an exciting new paradigm in the treatment of glioblastoma multiforme (GBM). The effective treatment of GBM will likely require a compound with th...

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Veröffentlicht in:	Journal of medicinal chemistry Jg. 67; H. 4; S. 3090 - 3111
Hauptverfasser:	Pike, Kurt G., Hunt, Thomas A., Barlaam, Bernard, Benstead, David, Cadogan, Elaine, Chen, Kan, Cook, Calum R., Colclough, Nicola, Deng, Chao, Durant, Stephen T., Eatherton, Andrew, Goldberg, Kristin, Johnstro''m, Peter, Liu, Libin, Liu, Zhaoqun, Nissink, J. Willem M., Pang, Chengling, Pass, Martin, Robb, Graeme R., Roberts, Caroline, Schou, Magnus, Steward, Oliver, Sykes, Andy, Yan, Yumei, Zhai, Baochang, Zheng, Li
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WASHINGTON Amer Chemical Soc 22.02.2024
Schlagworte:	Animals Ataxia Telangiectasia - drug therapy Ataxia Telangiectasia Mutated Proteins ATP Binding Cassette Transporter, Subfamily G, Member 2 Blood-Brain Barrier - metabolism Chemistry, Medicinal Glioblastoma - drug therapy Humans Life Sciences & Biomedicine Neoplasm Proteins Pharmacology & Pharmacy Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyridines Quinolones Science & Technology POTENT DESIGN ALIGNMENT PROTEIN-KINASE GLIOMA ATM CARBOXAMIDES MULTIPARAMETER OPTIMIZATION CANCER STRATEGIES
ISSN:	0022-2623, 1520-4804, 1520-4804
Online-Zugang:	Weitere Angaben
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