Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths

Childhood irritability is a common, impairing problem with changing age-related manifestations that predict long-term adverse outcomes. However, more investigation of overall and age-specific neural correlates is needed. Because youths with irritability exhibit exaggerated responses to frustrating s...

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Vydané v:The American journal of psychiatry Ročník 176; číslo 1; s. 67
Hlavní autori: Tseng, Wan-Ling, Deveney, Christen M, Stoddard, Joel, Kircanski, Katharina, Frackman, Anna E, Yi, Jennifer Y, Hsu, Derek, Moroney, Elizabeth, Machlin, Laura, Donahue, Laura, Roule, Alexandra, Perhamus, Gretchen, Reynolds, Richard C, Roberson-Nay, Roxann, Hettema, John M, Towbin, Kenneth E, Stringaris, Argyris, Pine, Daniel S, Brotman, Melissa A, Leibenluft, Ellen
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.01.2019
Predmet:
Adolescent
Age Factors
Attention - physiology
Brain - diagnostic imaging
Brain - drug effects
Brain - physiopathology
Child
Female
Frustration
Humans
Irritable Mood - physiology
Magnetic Resonance Imaging - methods
Male
Neurodevelopmental Disorders - diagnosis
Neurodevelopmental Disorders - physiopathology
Neurodevelopmental Disorders - psychology
Neurodevelopmental Disorders - therapy
Psychological Techniques
Psychotropic Drugs - therapeutic use
Frustrative Non-Reward
fMRI
Irritability
Attention Orienting
Age
ISSN:1535-7228, 1535-7228
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Shrnutí:Childhood irritability is a common, impairing problem with changing age-related manifestations that predict long-term adverse outcomes. However, more investigation of overall and age-specific neural correlates is needed. Because youths with irritability exhibit exaggerated responses to frustrating stimuli, the authors used a frustration functional MRI (fMRI) paradigm to examine associations between irritability and neural activation and tested the moderating effect of age. The authors studied a transdiagnostic sample of 195 youths with varying levels of irritability (disruptive mood dysregulation disorder, N=52; anxiety disorder, N=42; attention deficit hyperactivity disorder, N=40; and healthy volunteers, N=61). Irritability was measured by parent and child reports on the Affective Reactivity Index. The fMRI paradigm was a cued-attention task differentiating neural activity in response to frustration (rigged feedback) from activity during attention orienting in the trial following frustration. Whole-brain activation analyses revealed associations with irritability during attention orienting following frustration. Irritability was positively associated with frontal-striatal activation, specifically in the dorsolateral prefrontal cortex, inferior frontal gyrus, and caudate. Age moderated the association between irritability and activation in some frontal and posterior regions (the anterior cingulate cortex, medial frontal gyrus, cuneus, precuneus, and superior parietal lobule [F=19.04-28.51, df=1, 189, partial eta squared=0.09-0.13]). Specifically, higher irritability was more strongly related to increased activation in younger youths compared with older youths. Following frustration, levels of irritability correlated with activity in neural systems mediating attention orienting, top-down regulation of emotions, and motor execution. Although most associations were independent of age, dysfunction in the anterior cingulate cortex and posterior regions was more pronounced in young children with irritability.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1535-7228
1535-7228
DOI:10.1176/appi.ajp.2018.18040491