Conserved residues of the immunosuppressive domain of MLV are essential for regulating the fusion-critical SU-TM disulfide bond

The Env protein of murine leukemia virus (MLV) is the prototype of a large clade of retroviral fusogens, collectively known as gamma-type Envs. Gamma-type Envs are found in retroviruses and endogenous retroviruses (ERVs) representing a broad range of vertebrate hosts. All gamma-type Envs contain a h...

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Bibliographic Details
Published in:	Journal of virology Vol. 98; no. 11; p. e0098924
Main Authors:	Hogan, Victoria A, Harmon, Julia, Cid-Rosas, Miguel, Hall, Laura R, Johnson, Welkin E
Format:	Journal Article
Language:	English
Published:	United States 19.11.2024
Subjects:	Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Animals Cell Line Conserved Sequence Disulfides - metabolism HEK293 Cells Humans Membrane Fusion Mice Protein Domains Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Virus Internalization fusion murine leukemia virus infectivity gamma-type Env immunosuppressive domain envelope glycoprotein
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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