Nationwide Surveillance of Novel Oxazolidinone Resistance Gene optrA in Enterococcus Isolates in China from 2004 to 2014

A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0...

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Vydáno v:	Antimicrobial agents and chemotherapy Ročník 60; číslo 12; s. 7490 - 7493
Hlavní autoři:	Cui, Lanqing, Wang, Yang, Lv, Yuan, Wang, Shan, Song, Yunjia, Li, Yun, Liu, Jian, Xue, Feng, Yang, Weiwei, Zhang, Jia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2016
Témata:	Anti-Bacterial Agents - pharmacology China - epidemiology Drug Resistance, Bacterial - genetics Electrophoresis, Gel, Pulsed-Field Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Enterococcus faecalis - growth & development Enterococcus faecalis - isolation & purification Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - growth & development Enterococcus faecium - isolation & purification Genes, Bacterial Genotype Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - microbiology Humans Microbial Sensitivity Tests Multilocus Sequence Typing Mutation Oxazolidinones - pharmacology Public Health Surveillance
ISSN:	1098-6596
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Shrnutí:	A total of 2,201 nonduplicate enterococcal isolates collected from 29 hospitals in 23 cities in China between 2004 and 2014 were screened for the oxazolidinone resistance gene optrA; 45 isolates (2.0%) were optrA positive with 11 OptrA variants identified. The positive rate of optrA increased from 0.4% to 3.9% during the 10-year surveillance period. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence type (MLST) analysis revealed that 37 optrA-positive Enterococcus faecalis isolates clustered into 25 PFGE patterns and 21 sequence types, while 6 Enterococcus faecium isolates represented 6 PFGE patterns and 6 sequence types. The present study underscores the importance of routine and persistent monitoring of oxazolidinone resistance and optrA gene.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1098-6596
DOI:	10.1128/AAC.01256-16