The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

Ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG) are affected by induction of metabolizing enzymes and efflux transporters caused by rifampicin (RIF). This complicates the treatment of people living with HIV (PLWH) diagnosed with tuberculosis. Recent data showed that doubling DRV/r dose di...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 66; no. 6; p. e0013622
Main Authors:	De Nicolò, Amedeo, Calcagno, Andrea, Motta, Ilaria, De Vivo, Elisa, D'Avolio, Antonio, Di Perri, Giovanni, Wiesner, Lubbe, Ebrahim, Isma-Eel, Maartens, Gary, Orrell, Catherine, McIlleron, Helen
Format:	Journal Article
Language:	English
Published:	United States 21.06.2022
Subjects:	Anti-HIV Agents - pharmacokinetics Chromatography, Liquid Cross-Over Studies Darunavir - pharmacokinetics Heterocyclic Compounds, 3-Ring HIV Infections - drug therapy HIV Protease Inhibitors - pharmacology Humans Leukocytes, Mononuclear Oxazines Piperazines Pyridones Rifampin - pharmacokinetics Rifampin - therapeutic use Ritonavir - pharmacology Tandem Mass Spectrometry rifampicin drug interactions pharmacokinetics darunavir dolutegravir PBMC drug-drug interaction
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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