Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resista...

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Vydáno v:Antimicrobial agents and chemotherapy Ročník 65; číslo 1
Hlavní autoři: Kebriaei, Razieh, Lev, Katherine L, Stamper, Kyle C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 16.12.2020
Témata:
bacteriophage
infective endocarditis
combination
ISSN:1098-6596, 1098-6596
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Shrnutí:This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant (MRSA) infections.
Bibliografie:ObjectType-Article-1
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ISSN:1098-6596
1098-6596
DOI:10.1128/AAC.01863-20