Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resista...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy Vol. 65; no. 1
Main Authors: Kebriaei, Razieh, Lev, Katherine L, Stamper, Kyle C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J
Format: Journal Article
Language:English
Published: United States 16.12.2020
Subjects:
bacteriophage
infective endocarditis
combination
ISSN:1098-6596, 1098-6596
Online Access:Get more information
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Summary:This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant (MRSA) infections.
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ISSN:1098-6596
1098-6596
DOI:10.1128/AAC.01863-20