Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an In Vitro Pharmacokinetic/Pharmacodynamic Model

This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resista...

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Vydáno v:Antimicrobial agents and chemotherapy Ročník 65; číslo 1
Hlavní autoři: Kebriaei, Razieh, Lev, Katherine L, Stamper, Kyle C, Lehman, Susan M, Morales, Sandra, Rybak, Michael J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 16.12.2020
Témata:
bacteriophage
infective endocarditis
combination
ISSN:1098-6596, 1098-6596
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Abstract This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant (MRSA) infections.
AbstractList This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in vitro in 24-h time-kill settings and in ex vivo simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant Staphylococcus aureus (MRSA) infections.This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in vitro in 24-h time-kill settings and in ex vivo simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant Staphylococcus aureus (MRSA) infections.
This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in 24-h time-kill settings and in simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant (MRSA) infections.
Author Rybak, Michael J
Stamper, Kyle C
Lev, Katherine L
Lehman, Susan M
Morales, Sandra
Kebriaei, Razieh
Author_xml – sequence: 1
  givenname: Razieh
  surname: Kebriaei
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  organization: Anti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
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  givenname: Katherine L
  surname: Lev
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  organization: Anti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
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  organization: Anti-Infective Research Laboratory, College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
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  givenname: Susan M
  surname: Lehman
  fullname: Lehman, Susan M
  organization: AmpliPhi Biosciences Corporation, San Diego, California, USA
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  givenname: Sandra
  surname: Morales
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  surname: Rybak
  fullname: Rybak, Michael J
  email: m.rybak@wayne.edu
  organization: Detroit Receiving and University Health Center, Detroit, Michigan, USA
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