Pharmacokinetics, Safety, and Dosing of Novel Pediatric Levofloxacin Dispersible Tablets in Children with Multidrug-Resistant Tuberculosis Exposure

This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged <5 years who had household multidrug-resistant tuberculosus (MDR-TB) exposure. The current data were pooled with previously published data from children (  = 109) with MDR-TB receivi...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy Vol. 63; no. 4
Main Authors: Garcia-Prats, Anthony J, Purchase, Susan E, Osman, Muhammad, Draper, Heather R, Schaaf, H Simon, Wiesner, Lubbe, Denti, Paolo, Hesseling, Anneke C
Format: Journal Article
Language:English
Published: United States 01.04.2019
Subjects:
Antitubercular Agents - administration & dosage
Antitubercular Agents - adverse effects
Antitubercular Agents - pharmacokinetics
Biological Availability
Child, Preschool
Female
Humans
Infant
Levofloxacin - administration & dosage
Levofloxacin - adverse effects
Levofloxacin - pharmacokinetics
Male
Placebos
Tablets
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - prevention & control
bioavailability
children
levofloxacin
formulation
pharmacokinetics
multidrug-resistant tuberculosis
dispersible tablets
ISSN:1098-6596, 1098-6596
Online Access:Get more information
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Summary:This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged <5 years who had household multidrug-resistant tuberculosus (MDR-TB) exposure. The current data were pooled with previously published data from children (  = 109) with MDR-TB receiving adult (250-mg) levofloxacin tablets, using nonlinear mixed-effects modelling. The adult tablets had 41% lower bioavailability than the novel dispersible tablets, resulting in much higher exposures with the dispersible tablets with the same dose.
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ISSN:1098-6596
1098-6596
DOI:10.1128/AAC.01865-18