Catalysis of oxidative protein folding by small-molecule diselenides

The production of recombinant, disulfide-containing proteins often requires oxidative folding in vitro. Here, we show that diselenides, such as selenoglutathione, catalyze oxidative protein folding by O 2. Substantially lower concentrations of a redox buffer composed of selenoglutathione and the thi...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 47; no. 27; p. 6985
Main Authors:	Beld, Joris, Woycechowsky, Kenneth J, Hilvert, Donald
Format:	Journal Article
Language:	English
Published:	United States 08.07.2008
Subjects:	Catalysis Glutathione - metabolism Kinetics Oxidation-Reduction Protein Folding Ribonuclease, Pancreatic - chemistry Ribonuclease, Pancreatic - metabolism Selenium Compounds - metabolism
ISSN:	1520-4995, 1520-4995
Online Access:	Get more information
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