Amyloid protofibril is highly voluminous and compressible

We report here results of the first direct measurement of partial volume and compressibility changes of a protein as it forms an amyloid protofibril. We use a high precision density meter and an ultrasonic velocity meter on a solution of intrinsically denatured, disulfide-deficient variant of hen ly...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 46; no. 37; p. 10444
Main Authors:	Akasaka, Kazuyuki, Latif, Abdul Raziq Abdul, Nakamura, Akihiro, Matsuo, Koichi, Tachibana, Hideki, Gekko, Kunihiko
Format:	Journal Article
Language:	English
Published:	United States 18.09.2007
Subjects:	Amyloid - chemistry Animals Biomechanical Phenomena Circular Dichroism Kinetics Muramidase - chemistry Time Factors Ultrasonics
ISSN:	0006-2960
Online Access:	Get more information
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