Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen β-Lactamases from Burkholderia spp

Antimicrobial resistance (AMR) is a global threat, with species contributing significantly to difficult-to-treat infections. The Pen family of β-lactamases are produced by all spp., and their mutation or overproduction leads to the resistance of β-lactam antibiotics. Here we investigate the dynamic...

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Vydané v:	Journal of chemical information and modeling Ročník 65; číslo 10; s. 5086
Hlavní autori:	Gu, Jing, Agarwal, Pratul K, Bonomo, Robert A, Haider, Shozeb
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 26.05.2025
Predmet:	beta-Lactamases - chemistry beta-Lactamases - genetics beta-Lactamases - metabolism Burkholderia - enzymology Catalytic Domain Evolution, Molecular Markov Chains Molecular Dynamics Simulation Mutation
ISSN:	1549-960X, 1549-960X
On-line prístup:	Zistit podrobnosti o prístupe
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