Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen β-Lactamases from Burkholderia spp

Antimicrobial resistance (AMR) is a global threat, with species contributing significantly to difficult-to-treat infections. The Pen family of β-lactamases are produced by all spp., and their mutation or overproduction leads to the resistance of β-lactam antibiotics. Here we investigate the dynamic...

Full description

Bibliographic Details

Published in:	Journal of chemical information and modeling Vol. 65; no. 10; p. 5086
Main Authors:	Gu, Jing, Agarwal, Pratul K, Bonomo, Robert A, Haider, Shozeb
Format:	Journal Article
Language:	English
Published:	United States 26.05.2025
Subjects:	beta-Lactamases - chemistry beta-Lactamases - genetics beta-Lactamases - metabolism Burkholderia - enzymology Catalytic Domain Evolution, Molecular Markov Chains Molecular Dynamics Simulation Mutation
ISSN:	1549-960X, 1549-960X
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!