Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

The transient receptor potential (TRP) family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. TRPM8, a member of the melastatin subfamily, is activated by cold temperatures (<28 degrees C), and antagonists of this channel have t...

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Vydané v:	ACS medicinal chemistry letters Ročník 6; číslo 4; s. 419 - 424
Hlavní autori:	Andrews, Mark D., af Forselles, Kerry, Beaumont, Kevin, Galan, Sebastien R. G., Glossop, Paul A., Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S., Lunn, Graham, Maw, Graham, Owen, Robert M., Pryde, David C., Roberts, Dannielle, Thien Duc Tran
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WASHINGTON Amer Chemical Soc 09.04.2015
Predmet:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology pain DESIGN SERIES PP-05105679 clinical tool BODY-TEMPERATURE thermoregulation TRP channel PHARMACOLOGICAL BLOCKADE DRUG-DISCOVERY POTENT hypothermia ion channel CHANNELS TRPM8 PF-05105679
ISSN:	1948-5875, 1948-5875
On-line prístup:	Zistit podrobnosti o prístupe
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