Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

The increase in the incidence of antibiotic-resistant ( ) associated infections necessitates the urgent development of novel therapeutic strategies and antibacterial drugs. Antivirulence strategy is an especially compelling alternative strategy due to its low selective pressure for the development o...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry Vol. 67; no. 48; p. 13195
Main Authors: Wu, Shuai-Cheng, Liu, Fei, Zhu, Kui, Shen, Jian-Zhong
Format: Journal Article
Language:English
Published: United States 04.12.2019
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological Products - pharmacology
Drug Resistance, Bacterial
Humans
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - metabolism
Virulence Factors - antagonists & inhibitors
Virulence Factors - genetics
Virulence Factors - metabolism
natural products
microorganisms
plants
Staphylococcus aureus
antivirulence strategy
ISSN:1520-5118, 1520-5118
Online Access:Get more information
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Summary:The increase in the incidence of antibiotic-resistant ( ) associated infections necessitates the urgent development of novel therapeutic strategies and antibacterial drugs. Antivirulence strategy is an especially compelling alternative strategy due to its low selective pressure for the development of drug resistance in bacteria. Plants and microorganisms are not only important food and medicinal resources but also serve as sources for the discovery of natural products that target bacterial virulence factors. This review discusses the mechanisms of the major virulence factors of , including the accessory gene regulator quorum-sensing system, bacterial biofilm formation, α-hemolysin, sortase A, and staphyloxanthin. We also provide an overview of natural products isolated from plants and microorganisms with activity against the major virulence factors of and their adjuvant effects on existing antibiotics to overcome antibiotic-resistant . Finally, the limitations and solutions of these antivirulence compounds are discussed, which will help in the development of novel antibacterial drugs against antibiotic-resistant .
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ISSN:1520-5118
1520-5118
DOI:10.1021/acs.jafc.9b05595