TRPV1 Activation by Anandamide via a Unique Lipid Pathway

The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a un...

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Bibliographic Details
Published in:	Journal of chemical information and modeling Vol. 61; no. 12; p. 5742
Main Authors:	Muller, Chanté, Lynch, Diane L, Hurst, Dow P, Reggio, Patricia H
Format:	Journal Article
Language:	English
Published:	United States 27.12.2021
Subjects:	Arachidonic Acids - pharmacology Cannabinoid Receptor Modulators - metabolism Endocannabinoids Polyunsaturated Alkamides - pharmacology Receptor, Cannabinoid, CB1 - metabolism TRPV Cation Channels
ISSN:	1549-960X, 1549-960X
Online Access:	Get more information
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Summary:	The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correspondence-1 content type line 23
ISSN:	1549-960X 1549-960X
DOI:	10.1021/acs.jcim.1c00893