TRPV1 Activation by Anandamide via a Unique Lipid Pathway

The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a un...

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Vydané v:Journal of chemical information and modeling Ročník 61; číslo 12; s. 5742
Hlavní autori: Muller, Chanté, Lynch, Diane L, Hurst, Dow P, Reggio, Patricia H
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 27.12.2021
Predmet:
Arachidonic Acids - pharmacology
Cannabinoid Receptor Modulators - metabolism
Endocannabinoids
Polyunsaturated Alkamides - pharmacology
Receptor, Cannabinoid, CB1 - metabolism
TRPV Cation Channels
ISSN:1549-960X, 1549-960X
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Shrnutí:The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 23
ISSN:1549-960X
1549-960X
DOI:10.1021/acs.jcim.1c00893