Medical Biotechnology
In this jargon-free, easy-to-read textbook, the authors demystify the discipline of medical biotechnology and present a roadmap that provides a fundamental understanding of the wide-ranging approaches pursued by scientists to diagnose, prevent, and treat medical conditions. This book is written to e...
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| Hauptverfasser: | , , |
|---|---|
| Format: | E-Book Buch |
| Sprache: | Englisch |
| Veröffentlicht: |
Washington, DC
American Society for Microbiology (ASM)
2014
Wiley ASM ASM Press |
| Ausgabe: | 1 |
| Schriftenreihe: | ASM Books |
| Schlagworte: | |
| ISBN: | 155581705X, 9781555817053 |
| Online-Zugang: | Volltext |
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Inhaltsangabe:
- Title Page Preface Table of Contents Section 1. The Biology behind the Technology 1. Fundamental Technologies 2. Fundamental Concepts in Immunology 3. The Genetic Basis of Disease 4. Immune Pathogenesis 5. Microbial Pathogenesis Section 2. Production of Therapeutic Agents 6. Modulation of Gene Expression 7. Genetic Engineering of Plants Section 3. Diagnosing and Treating Human Disease 8. Molecular Diagnostics 9. Protein Therapeutics 10. Nucleic Acid Therapeutic Agents and Human Gene Therapy 11. Vaccines 12. Societal Issues Glossary Index
- Cover -- Contents -- Preface -- About the Authors -- SECTION I: The Biology behind the Technology -- 1 Fundamental Technologies -- Molecular Cloning -- Genomic Libraries -- Amplification of DNA Using PCR -- DNA Sequencing Technologies -- Sequencing Whole Genomes -- Genomics -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 2 Fundamental Concepts in Immunology -- The Immune Response -- Functions of the Immune System -- Cells of the Immune System: Cell-Mediated Immunity -- Tissues of the Immune System -- Humoral Immunity -- Types of Antibodies: Applications -- Immunological Techniques -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 3 The Genetic Basis of Disease -- Chromosomal Disorders and Gene Mapping -- Single-Gene Disorders -- Polygenic Disorders and Gene Clustering -- Mitochondrial Disorders -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 4 Immune Pathogenesis -- Models of Immune System Lesions -- Inflammation and Immune Hypersensitivity Disorders -- Immunodeficiency Disorders and Defects in Development of the Immune System -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 5 Microbial Pathogenesis -- Introduction -- Bacterial Infections -- Viral Infections -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- SECTION II: Production of Therapeutic Agents -- 6 Modulation of Gene Expression -- Manipulating Gene Expression in Prokaryotes -- Heterologous Protein Production in Eukaryotic Cells -- Directed Mutagenesis -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 7 Genetic Engineering of Plants -- Plant Transformation with the Ti Plasmid of A. tumefaciens -- Physical Transfer of Genes to Plants -- Chloroplast Engineering -- Transient Gene Expression -- Molecular Pharming -- Edible Vaccines -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- SECTION III: Diagnosing and Treating Human Disease -- 8 Molecular Diagnostics
- Immunological Approaches To Detect Protein Biomarkers of Disease -- DNA-Based Approaches to Disease Diagnosis -- Detecting RNA Signatures of Disease -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 9 Protein Therapeutics -- Pharmaceuticals -- Recombinant Antibodies -- Enzymes -- Lactic Acid Bacteria -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 10 Nucleic Acid Therapeutic Agents and Human Gene Therapy -- Treating Genetic and Nongenetic Disorders -- Targeting Specific mRNAs and DNAs -- Viral Delivery Systems -- Nonviral Nucleic Acid Delivery Systems -- Gene Therapy -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 11 Vaccines -- Vaccination: Overview -- Subunit Vaccines -- Peptide Vaccines -- Dendritic Cell Vaccines -- DNA Vaccines -- Attenuated Vaccines -- Vector Vaccines -- Adjuvants -- Systems Biology and Evaluation of Vaccines -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- 12 Societal Issues -- Safety and Ethical Issues -- Patenting Biotechnology -- Economic Issues -- SUMMARY -- REVIEW QUESTIONS -- REFERENCES -- Glossary -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z