Hardware-Software Design of a Smart Sensor for Fully-Electronic DNA Hybridization Detection

This paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart...

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Bibliographic Details
Published in:Design, Automation and Test in Europe pp. 198 - 203
Main Authors: Stagni, Claudio, Guiducci, Carlotta, Lanzoni, Massimo, Benini, Luca, Ricco, Bruno
Format: Conference Proceeding
Language:English
Published: Washington, DC, USA IEEE Computer Society 07.03.2005
IEEE
Series:ACM Conferences
Subjects:
Applied computing > Life and medical sciences > Computational biology
Applied computing > Life and medical sciences > Genetics
Applied computing > Life and medical sciences > Systems biology
Biosensors
Computer architecture
DNA
Electric variables measurement
Electrodes
Hardware
Hardware > Communication hardware, interfaces and storage
Hardware > Integrated circuits > Interconnect > Input > output circuits
Impedance measurement
Intelligent sensors
Sensor phenomena and characterization
Signal processing
Software and its engineering > Software notations and tools > Context specific languages > Domain specific languages
Software and its engineering > Software organization and properties > Software system structures > Software architectures
ISBN:9780769522883, 0769522882
ISSN:1530-1591
Online Access:Get full text
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Summary:This paper describes the design of a smart sensor for label-free detection of DNA hybridization. The sensor is based on a direct electrical transduction principle: it measures impedance variation at the interface between a bio-functionalized electrode and a solution containing the analyte. The smart sensor includes a complete signal conditioning and processing subsystem based on an embedded μ-controller. We outline the sensor architecture, and we describe in details board-level integration as well as hardware and software implementation and design choices. The accuracy of our embedded solution has been evaluated by comparing it with a high-cost laboratory setup. Moreover, we provide measurements of real sensing structures which demonstrate in field the functionality of our system.
Bibliography:SourceType-Conference Papers & Proceedings-1
ObjectType-Conference Paper-1
content type line 25
ISBN:9780769522883
0769522882
ISSN:1530-1591
DOI:10.1109/DATE.2005.173