Probing the Carboxyester Side Chain in Controlled Deactivation (−)‑Δ8‑Tetrahydrocannabinols

We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a metabolically labile ester group at strategic positions within the THC structure. We have now synthesized a series of (−)-Δ8-THC analogues encomp...

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Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 58; no. 2; pp. 665 - 681
Main Authors:	Nikas, Spyros P, Sharma, Rishi, Paronis, Carol A, Kulkarni, Shashank, Thakur, Ganesh A, Hurst, Dow, Wood, JodiAnne T, Gifford, Roger S, Rajarshi, Girija, Liu, Yingpeng, Raghav, Jimit Girish, Guo, Jason Jianxin, Järbe, Torbjörn U.C, Reggio, Patricia H, Bergman, Jack, Makriyannis, Alexandros
Format:	Journal Article
Language:	English
Published:	American Chemical Society 22.01.2015
ISSN:	0022-2623, 1520-4804
Online Access:	Get full text
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