Marek’s disease: A global challenge to poultry health and productivity.

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Titel:	Marek’s disease: A global challenge to poultry health and productivity.
Autoren:	Mulyati, Sri¹ sri-m@fkh.unair.ac.id, Mustofa, Imam¹, Khairullah, Aswin Rafif², Kusala, Muhammad Khaliim Jati², Fauziah, Ima², Ahmad, Riza Zainuddin², Ekawasti, Fitrine², Prihandani, Sri Suryatmiati², Furqoni, Abdul Hadi³, Wardhani, Bantari Wisynu Kusuma⁴, Kurniasih, Dea Anita Ariani⁵, Khalisa, Andi Thafida⁶, Moses, Ikechukwu Benjamin⁷, Akintunde, Adeyinka Oye⁸, Pratama, Bima Putra⁹, Raharjo, Prima Puji¹⁰, Fauzia, Kartika Afrida¹¹, Wibowo, Syahputra¹²
Quelle:	Open Veterinary Journal. 2025, Vol. 15 Issue 10, p4797-4813. 17p.
Publikationsart:	Article
Schlagworte:	Marek's disease, Poultry, Pathogenesis, Biosecurity, Epidemiology, Vaccination, Economic impact
Author-Supplied Keywords:	biosecurity measures Marek’s disease Virus Poultry health Viral pathogenesis
Abstract:	Marek’s disease is a neuropathic and lymphoproliferative viral condition that primarily affects chickens and occasionally affects quail and turkeys. It is caused by the Marek’s disease virus (MDV), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Mardivirus, which comprises three distinct species: MDV-1, MDV-2, and MDV-3 (herpesvirus of turkeys). Marek’s disease remains a significant global challenge despite the availability of vaccines, with outbreaks still occurring in many poultry-producing regions due to the evolving virulence of the virus and incomplete protection. The current literature provides abundant information on the etiology, pathogenesis, and control of Marek’s Disease; however, an up-to-date, comprehensive synthesis that integrates recent molecular insights, epidemiological patterns, and advanced control strategies is lacking. This review addresses this gap by systematically compiling and analyzing recent studies published in peer-reviewed journals, selected through database searches in PubMed, Scopus, and Web of Science using predefined inclusion and exclusion criteria. Key findings highlight the complexity of MDV pathogenesis, virus persistence in the poultry environment, and limitations of existing vaccines in achieving sterile immunity. The review also underscores the importance of combining vaccination with genetic selection and strict biosecurity to mitigate economic losses. Understanding these interconnected factors is crucial for guiding future research and improving disease management strategies in the poultry industry. [ABSTRACT FROM AUTHOR]
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Author Affiliations:	¹Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia. ²Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia. ³Center for Biomedical Research, National Research and Innovation Agency (BRIN), Bogor, Indonesia. ⁴Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Bogor, Indonesia. ⁵Research Center for Public Health and Nutrition, National Research and Innovation Agency (BRIN), Bogor, Indonesia. ⁶Faculty of Military Pharmacy, Universitas Pertahanan, Bogor, Indonesia. ⁷Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria. ⁸Department of Agriculture and Industrial Technology, Babcock University, Ilishan Remo, Nigeria. ⁹Research Center for Agroindustry, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia. ¹⁰Balai Besar Pelatihan Peternakan (BBPP) Batu, Kementerian Pertanian, Malang, Indonesia. ¹¹Research Center for Preclinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Bogor, Indonesia. ¹²Eijkman Research Center for Molecular Biology, National Research and Innovation Agency (BRIN), Bogor, Indonesia.
ISSN:	2226-4485
DOI:	10.5455/OVJ.2025.v15.i10.2
Dokumentencode:	190365282
Datenbank:	Veterinary Source

Beschreibung
Abstract:	Marek’s disease is a neuropathic and lymphoproliferative viral condition that primarily affects chickens and occasionally affects quail and turkeys. It is caused by the Marek’s disease virus (MDV), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Mardivirus, which comprises three distinct species: MDV-1, MDV-2, and MDV-3 (herpesvirus of turkeys). Marek’s disease remains a significant global challenge despite the availability of vaccines, with outbreaks still occurring in many poultry-producing regions due to the evolving virulence of the virus and incomplete protection. The current literature provides abundant information on the etiology, pathogenesis, and control of Marek’s Disease; however, an up-to-date, comprehensive synthesis that integrates recent molecular insights, epidemiological patterns, and advanced control strategies is lacking. This review addresses this gap by systematically compiling and analyzing recent studies published in peer-reviewed journals, selected through database searches in PubMed, Scopus, and Web of Science using predefined inclusion and exclusion criteria. Key findings highlight the complexity of MDV pathogenesis, virus persistence in the poultry environment, and limitations of existing vaccines in achieving sterile immunity. The review also underscores the importance of combining vaccination with genetic selection and strict biosecurity to mitigate economic losses. Understanding these interconnected factors is crucial for guiding future research and improving disease management strategies in the poultry industry. [ABSTRACT FROM AUTHOR]
ISSN:	22264485
DOI:	10.5455/OVJ.2025.v15.i10.2