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Bluetongue in ruminants: Global epidemiology, pathogenesis, and advances in diagnostic and control strategies within a One Health framework.

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Titel: Bluetongue in ruminants: Global epidemiology, pathogenesis, and advances in diagnostic and control strategies within a One Health framework.
Autoren: Ayuti, Siti Rani1,2 sitirani_ayuti@usk.ac.id, Khairullah, Aswin Rafif3 aswinrafif@gmail.com, Lamid, Mirni4 mirnylamid@fkh.unair.ac.id, Warsito, Sunaryo Hadi4 sunaryo-h-w@fkh.unair.ac.id, Al Arif, Mohammad Anam4 moh-a-a-a@fkh.unair.ac.id, Kim, Eun Joong5 ejkim2011@knu.ac.kr, Moses, Ikechukwu Benjamin6 ikechukwumoses937@gmail.com, Shin, Sangsu5 sss@knu.ac.kr, Wardhani, Bantari Wisynu Kusuma7 bantariwisynu@gmail.com, Wasito, Wasito3 wasi010@brin.go.id, Khalisa, Andi Thafida8 andi.thafidakhalisa2103@gmail.com, Ahmad, Riza Zainuddin3 riza011@brin.go.id
Quelle: Veterinary World. Oct2025, Vol. 18 Issue 10, p3070-3093. 24p.
Publikationsart: Literature Review
Schlagworte: Bluetongue, Ruminants, Pathogenesis, Diagnostic services, Epidemiology, Medical protocols, Climate change, Public health
Author-Supplied Keywords: bluetongue virus
Culicoides vectors
diagnostics
epidemiology
livestock disease control
One Health
vaccination
Abstract: Bluetongue (BT) is an economically important viral disease of domestic and wild ruminants, caused by the bluetongue virus (BTV), and transmitted primarily by Culicoides midges. The virus has at least 28 known serotypes and several emerging strains, with its distribution expanding beyond traditional endemic zones due to climate change and global trade. This review summarizes recent developments in the epidemiology, molecular characterization, diagnostics, vaccines, and control of BT, with an emphasis on its implications within the One Health framework. A comprehensive literature search covering studies from 2000 to 2025 revealed significant outbreaks in Europe (2024–2025) involving BTV-3 and BTV-12, as well as the emergence of novel serotypes in Asia and Africa. Global economic losses exceed USD 3 billion annually due to mortality, production losses, and trade restrictions. Advances in molecular diagnostics, such as reverse transcription polymerase chain reaction, whole-genome sequencing, and rapid field assays like loop-mediated isothermal amplification and clustered regularly interspaced short palindromic repeats -based platforms, have improved surveillance and serotype identification. Although vaccination remains the cornerstone of BT control, current live and inactivated vaccines are limited by serotype specificity and reassortment risks, highlighting the need for new-generation virus-like particle, recombinant, DNA, and mRNA-based vaccines. Persistent challenges include the absence of differentiating infected from vaccinated animals -compatible polyvalent vaccines, incomplete knowledge of wildlife reservoirs, and uneven surveillance capacities worldwide. Strengthening integrated vector management, genomic monitoring, and climate-informed control strategies through a coordinated One Health approach will be vital to reduce the global burden of bluetongue. [ABSTRACT FROM AUTHOR]
Copyright of Veterinary World is the property of Veterinary World and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Author Affiliations: 1Doctoral Program of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
2Laboratory of Biochemistry, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
3Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, West Java, Indonesia.
4Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
5Department of Animal Science and Biotechnology, Kyungpook National University, Sangju, Republic of Korea.
6Department of Applied Microbiology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria.
7Research Center for Pharmaceutical Ingredients and Traditional Medicine, Bogor, West Java, Indonesia.
8The Pharmacist Professional Education Program, Faculty of Military Pharmacy, Universitas Pertahanan, Bogor, West Java, Indonesia.
ISSN: 0972-8988
DOI: 10.14202/vetworld.2025.3070-3093
Dokumentencode: 189111178
Datenbank: Veterinary Source
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  Data: Bluetongue in ruminants: Global epidemiology, pathogenesis, and advances in diagnostic and control strategies within a One Health framework.
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  Data: <searchLink fieldCode="AR" term="%22Ayuti%2C+Siti+Rani%22">Ayuti, Siti Rani</searchLink><relatesTo>1,2</relatesTo><i> sitirani_ayuti@usk.ac.id</i><br /><searchLink fieldCode="AR" term="%22Khairullah%2C+Aswin+Rafif%22">Khairullah, Aswin Rafif</searchLink><relatesTo>3</relatesTo><i> aswinrafif@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Lamid%2C+Mirni%22">Lamid, Mirni</searchLink><relatesTo>4</relatesTo><i> mirnylamid@fkh.unair.ac.id</i><br /><searchLink fieldCode="AR" term="%22Warsito%2C+Sunaryo+Hadi%22">Warsito, Sunaryo Hadi</searchLink><relatesTo>4</relatesTo><i> sunaryo-h-w@fkh.unair.ac.id</i><br /><searchLink fieldCode="AR" term="%22Al+Arif%2C+Mohammad+Anam%22">Al Arif, Mohammad Anam</searchLink><relatesTo>4</relatesTo><i> moh-a-a-a@fkh.unair.ac.id</i><br /><searchLink fieldCode="AR" term="%22Kim%2C+Eun+Joong%22">Kim, Eun Joong</searchLink><relatesTo>5</relatesTo><i> ejkim2011@knu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Moses%2C+Ikechukwu+Benjamin%22">Moses, Ikechukwu Benjamin</searchLink><relatesTo>6</relatesTo><i> ikechukwumoses937@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Shin%2C+Sangsu%22">Shin, Sangsu</searchLink><relatesTo>5</relatesTo><i> sss@knu.ac.kr</i><br /><searchLink fieldCode="AR" term="%22Wardhani%2C+Bantari+Wisynu+Kusuma%22">Wardhani, Bantari Wisynu Kusuma</searchLink><relatesTo>7</relatesTo><i> bantariwisynu@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Wasito%2C+Wasito%22">Wasito, Wasito</searchLink><relatesTo>3</relatesTo><i> wasi010@brin.go.id</i><br /><searchLink fieldCode="AR" term="%22Khalisa%2C+Andi+Thafida%22">Khalisa, Andi Thafida</searchLink><relatesTo>8</relatesTo><i> andi.thafidakhalisa2103@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Ahmad%2C+Riza+Zainuddin%22">Ahmad, Riza Zainuddin</searchLink><relatesTo>3</relatesTo><i> riza011@brin.go.id</i>
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  Data: <searchLink fieldCode="DE" term="%22Bluetongue%22">Bluetongue</searchLink><br /><searchLink fieldCode="DE" term="%22Ruminants%22">Ruminants</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogenesis%22">Pathogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+services%22">Diagnostic services</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+protocols%22">Medical protocols</searchLink><br /><searchLink fieldCode="DE" term="%22Climate+change%22">Climate change</searchLink><br /><searchLink fieldCode="DE" term="%22Public+health%22">Public health</searchLink>
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bluetongue (BT) is an economically important viral disease of domestic and wild ruminants, caused by the bluetongue virus (BTV), and transmitted primarily by Culicoides midges. The virus has at least 28 known serotypes and several emerging strains, with its distribution expanding beyond traditional endemic zones due to climate change and global trade. This review summarizes recent developments in the epidemiology, molecular characterization, diagnostics, vaccines, and control of BT, with an emphasis on its implications within the One Health framework. A comprehensive literature search covering studies from 2000 to 2025 revealed significant outbreaks in Europe (2024–2025) involving BTV-3 and BTV-12, as well as the emergence of novel serotypes in Asia and Africa. Global economic losses exceed USD 3 billion annually due to mortality, production losses, and trade restrictions. Advances in molecular diagnostics, such as reverse transcription polymerase chain reaction, whole-genome sequencing, and rapid field assays like loop-mediated isothermal amplification and clustered regularly interspaced short palindromic repeats -based platforms, have improved surveillance and serotype identification. Although vaccination remains the cornerstone of BT control, current live and inactivated vaccines are limited by serotype specificity and reassortment risks, highlighting the need for new-generation virus-like particle, recombinant, DNA, and mRNA-based vaccines. Persistent challenges include the absence of differentiating infected from vaccinated animals -compatible polyvalent vaccines, incomplete knowledge of wildlife reservoirs, and uneven surveillance capacities worldwide. Strengthening integrated vector management, genomic monitoring, and climate-informed control strategies through a coordinated One Health approach will be vital to reduce the global burden of bluetongue. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Veterinary World is the property of Veterinary World and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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