Plasma N-terminal pro-B-type natriuretic peptide and urinary aldosterone-to-creatinine ratio in healthy Chihuahuas.
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| Titel: | Plasma N-terminal pro-B-type natriuretic peptide and urinary aldosterone-to-creatinine ratio in healthy Chihuahuas. |
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| Autoren: | Galizzi, Alberto1 (AUTHOR), Dossi, Greta1 (AUTHOR), Pocar, Paola1 (AUTHOR), Borromeo, Vitaliano1 (AUTHOR), Locatelli, Chiara1 (AUTHOR) chiara.locatelli@unimi.it |
| Quelle: | BMC Veterinary Research. 11/1/2024, Vol. 20 Issue 1, p1-9. 9p. |
| Publikationsart: | Article |
| Schlagworte: | Chihuahua (Dog breed), Renin-angiotensin system, Peptides, Heart diseases, Median (Mathematics) |
| Author-Supplied Keywords: | Aldosterone Chihuahua Dogs Natriuretic peptide NT-proBNP |
| Abstract: | Background: Chihuahua represents an increasingly widespread breed predisposed to cardiac disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) might be a useful point-of-care biomarker for dogs suspected of having heart disease, but breed differences have been reported. The urinary aldosterone-to-creatinine ratio (UAldo: C) appears to be a good indicator of renin-angiotensin-aldosterone system activity in dogs, but Chihuahuas showed significantly higher UAldo: C than other breeds. The objective of this study was to assess preliminary breed-specific reference intervals for NT-proBNP and UAldo: C in healthy Chihuahuas and evaluate sex differences in these parameters. Results: Forty-three healthy Chihuahuas dogs were enrolled. The median NT-proBNP was 347 (125–515) pmol/L, and the median UAldo: C was 2.59 (1.57–4.61) µg/g. The NT-proBNP reference interval was 125 (90% CI 125–125) – 2121.4 (90% CI 941.6–2248) pmol/L. 91% of the Chihuahuas were below the nonbreed-specific cut-off (900 pmol/L). The UAldo: C reference interval was 0.6 (90% CI 0.5–0.9) – 16.8 (90% CI 10.9–27.4) µg/g. No significant sex differences in NT-proBNP or UAldo: C were found. Conclusions: The median value, interindividual coefficient of variation and reference interval of NT-proBNP were in line with those reported for other small breeds. In contrast to previous studies, no sex differences in NT-proBNP were detected. As previously suggested, Chihuahuas seem to be characterized by higher values of UAldo: C than other breeds. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1https://ror.org/00wjc7c48 Department of Veterinary Medicine and Animal Science, Università degli Studi di Milano, Via dell'Università 6, 26900, Lodi, Italy |
| Full Text Word Count: | 7324 |
| ISSN: | 1746-6148 |
| DOI: | 10.1186/s12917-024-04344-w |
| Dokumentencode: | 180626677 |
| Datenbank: | Veterinary Source |
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| Abstract: | Background: Chihuahua represents an increasingly widespread breed predisposed to cardiac disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) might be a useful point-of-care biomarker for dogs suspected of having heart disease, but breed differences have been reported. The urinary aldosterone-to-creatinine ratio (UAldo: C) appears to be a good indicator of renin-angiotensin-aldosterone system activity in dogs, but Chihuahuas showed significantly higher UAldo: C than other breeds. The objective of this study was to assess preliminary breed-specific reference intervals for NT-proBNP and UAldo: C in healthy Chihuahuas and evaluate sex differences in these parameters. Results: Forty-three healthy Chihuahuas dogs were enrolled. The median NT-proBNP was 347 (125–515) pmol/L, and the median UAldo: C was 2.59 (1.57–4.61) µg/g. The NT-proBNP reference interval was 125 (90% CI 125–125) – 2121.4 (90% CI 941.6–2248) pmol/L. 91% of the Chihuahuas were below the nonbreed-specific cut-off (900 pmol/L). The UAldo: C reference interval was 0.6 (90% CI 0.5–0.9) – 16.8 (90% CI 10.9–27.4) µg/g. No significant sex differences in NT-proBNP or UAldo: C were found. Conclusions: The median value, interindividual coefficient of variation and reference interval of NT-proBNP were in line with those reported for other small breeds. In contrast to previous studies, no sex differences in NT-proBNP were detected. As previously suggested, Chihuahuas seem to be characterized by higher values of UAldo: C than other breeds. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 17466148 |
| DOI: | 10.1186/s12917-024-04344-w |