The use of RNA interference for the management of arthropod pests in livestock farms.
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| Title: | The use of RNA interference for the management of arthropod pests in livestock farms. |
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| Authors: | Bonina, Valeria1 (AUTHOR), Arpaia, Salvatore2 (AUTHOR) salvatore.arpaia@enea.it |
| Source: | Medical & Veterinary Entomology. Dec2023, Vol. 37 Issue 4, p631-646. 16p. |
| Document Type: | Article |
| Subjects: | RNA interference, Agricultural pests, Pest control, Small interfering RNA, Animal welfare, Arthropod pests |
| Author-Supplied Keywords: | Acari biopesticides biosafety Diptera honeybees livestock pest management poultry |
| Abstract (English): | Pest management in farm animals is an important action to contain economic damage to livestock production and prevent transmission of severe diseases to the stock. The use of chemical insecticides is still the most common approach followed by farmers; however, avoiding possible toxic effects on animals is a fundamental task for pest control measures compatible with animal well‐being. Moreover, legal constraints and insurgence of resistance by target species to the available insecticidal compounds are increasingly complicating farmers' operations. Alternatives to chemical pesticides have been explored with some promising results in the area of biological control or the use of natural products as sprays. The application of RNA interference techniques has enabled the production of new means of pest control in agriculture, and it is opening a promising avenue for controlling arthropod pests of livestock. Transcript depletion of specific target genes of the recipient organisms is based on the action of double‐strand RNAs (dsRNA) capable of impairing the production of fundamental proteins. Their mode of action, based on the specific recognition of short genomic sequences, is expected to be highly selective towards non‐target organisms potentially exposed; in addition, there are physical and chemical barriers to dsRNA uptake by mammalian cells that render these products practically innocuous for higher animals. Summarising existing literature on gene silencing for main taxa of arthropod pests of livestock (Acarina, Diptera, Blattoidea), this review explores the perspectives of practical applications of dsRNA‐based pesticides against the main pests of farm animals. Knowledge gaps are summarised to stimulate additional research in this area. [ABSTRACT FROM AUTHOR] |
| Abstract (Italian): | Riassunto: La lotta ai parassiti negli animali da allevamento è una pratica importante per contenere i danni economici alle produzioni zootecniche e prevenire la trasmissione di gravi malattie al bestiame. L'uso di insetticidi chimici è ancora l'approccio più comune seguito dagli allevatori, ma evitare possibili effetti tossici sugli animali è un compito fondamentale per implementare misure di controllo dei parassiti compatibili con il benessere animale. Inoltre, i vincoli legali e l'insorgenza di resistenza da parte delle specie bersaglio ai composti insetticidi disponibili stanno complicando sempre più le operazioni degli allevatori. L'applicazione delle tecniche dell'RNA interferente (RNAi) ha consentito di ottenere nuovi mezzi per la lotta ai fitofagi in agricoltura e sta aprendo una strada promettente anche per il controllo degli artropodi parassiti del bestiame. La tecnica dell'RNAi si basa sull'azione di piccole molecole di RNA a doppia elica (dsRNA) in grado di silenziare specificamente i geni degli organismi bersaglio. Il loro meccanismo è in grado di garantire selettività nei confronti di organismi non bersaglio potenzialmente esposti, inoltre la presenza di barriere fisiche e chimiche all'assorbimento di RNA da parte delle cellule dei mammiferi rendono questi prodotti praticamente innocui per gli animali superiori. Riassumendo la letteratura esistente sul silenziamento genico per i principali taxa di artropodi parassiti del bestiame (Acarina, Diptera, Blattoidea), questa review esplora le prospettive delle applicazioni di pesticidi a base di RNA interferente contro i principali parassiti degli animali da allevamento. Vengono altresì indicati gli attuali limiti della conoscenza in questo campo per stimolare nuove ricerche in una prospettiva applicativa. [ABSTRACT FROM AUTHOR] |
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| Author Affiliations: | 1Department of Veterinary Medicine and Animal Productions, Università degli Studi di Napoli "Federico II", Naples, Italy 2ENEA, Italian National Agency for New Technologies, Energy and Sustainable Economic Development, TERIN‐BBC Research Centre Trisaia, Rotondella Matera,, Italy |
| Full Text Word Count: | 12883 |
| ISSN: | 0269-283X |
| DOI: | 10.1111/mve.12677 |
| Accession Number: | 173469569 |
| Database: | Veterinary Source |
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| Abstract: | Pest management in farm animals is an important action to contain economic damage to livestock production and prevent transmission of severe diseases to the stock. The use of chemical insecticides is still the most common approach followed by farmers; however, avoiding possible toxic effects on animals is a fundamental task for pest control measures compatible with animal well‐being. Moreover, legal constraints and insurgence of resistance by target species to the available insecticidal compounds are increasingly complicating farmers' operations. Alternatives to chemical pesticides have been explored with some promising results in the area of biological control or the use of natural products as sprays. The application of RNA interference techniques has enabled the production of new means of pest control in agriculture, and it is opening a promising avenue for controlling arthropod pests of livestock. Transcript depletion of specific target genes of the recipient organisms is based on the action of double‐strand RNAs (dsRNA) capable of impairing the production of fundamental proteins. Their mode of action, based on the specific recognition of short genomic sequences, is expected to be highly selective towards non‐target organisms potentially exposed; in addition, there are physical and chemical barriers to dsRNA uptake by mammalian cells that render these products practically innocuous for higher animals. Summarising existing literature on gene silencing for main taxa of arthropod pests of livestock (Acarina, Diptera, Blattoidea), this review explores the perspectives of practical applications of dsRNA‐based pesticides against the main pests of farm animals. Knowledge gaps are summarised to stimulate additional research in this area. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 0269283X |
| DOI: | 10.1111/mve.12677 |