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Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast

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Názov: Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
Autori: Malina, Carl, 1992, Brown, Rosemary, 1990, Björkeroth, Johan, 1990, Kerkhoven, Eduard, 1985, Nielsen, Jens B, 1962
Zdroj: Proceedings of the National Academy of Sciences of the United States of America. 118(51)
Predmety: Constraint-based modeling, Proteomics, Systems biology, Yeast, Crabtree effect
Popis: Aerobic fermentation, also referred to as the Crabtree effect in yeast, is a well-studied phenomenon that allows many eukaryal cells to attain higher growth rates at high glucose availability. Not all yeasts exhibit the Crabtree effect, and it is not known why Crabtree-negative yeasts can grow at rates comparable to Crabtree-positive yeasts. Here, we quantitatively compared two Crabtree-positive yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and two Crabtree-negative yeasts, Kluyveromyces marxianus and Scheffersomyces stipitis, cultivated under glucose excess conditions. Combining physiological and proteome quantification with genome-scale metabolic modeling, we found that the two groups differ in energy metabolism and translation efficiency. In Crabtree-positive yeasts, the central carbon metabolism flux and proteome allocation favor a glucose utilization strategy minimizing proteome cost as proteins translation parameters, including ribosomal content and/or efficiency, are lower. Crabtree-negative yeasts, however, use a strategy of maximizing ATP yield, accompanied by higher protein translation parameters. Our analyses provide insight into the underlying reasons for the Crabtree effect, demonstrating a coupling to adaptations in both metabolism and protein translation.
Popis súboru: electronic
Prístupová URL adresa: https://research.chalmers.se/publication/528253
https://research.chalmers.se/publication/528253/file/528253_Fulltext.pdf
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  Data: Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
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  Data: <searchLink fieldCode="AR" term="%22Malina%2C+Carl%22">Malina, Carl</searchLink>, 1992<br /><searchLink fieldCode="AR" term="%22Brown%2C+Rosemary%22">Brown, Rosemary</searchLink>, 1990<br /><searchLink fieldCode="AR" term="%22Björkeroth%2C+Johan%22">Björkeroth, Johan</searchLink>, 1990<br /><searchLink fieldCode="AR" term="%22Kerkhoven%2C+Eduard%22">Kerkhoven, Eduard</searchLink>, 1985<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+Jens+B%22">Nielsen, Jens B</searchLink>, 1962
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  Data: <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 118(51)
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  Data: <searchLink fieldCode="DE" term="%22Constraint-based+modeling%22">Constraint-based modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Systems+biology%22">Systems biology</searchLink><br /><searchLink fieldCode="DE" term="%22Yeast%22">Yeast</searchLink><br /><searchLink fieldCode="DE" term="%22Crabtree+effect%22">Crabtree effect</searchLink>
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  Label: Description
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  Data: Aerobic fermentation, also referred to as the Crabtree effect in yeast, is a well-studied phenomenon that allows many eukaryal cells to attain higher growth rates at high glucose availability. Not all yeasts exhibit the Crabtree effect, and it is not known why Crabtree-negative yeasts can grow at rates comparable to Crabtree-positive yeasts. Here, we quantitatively compared two Crabtree-positive yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and two Crabtree-negative yeasts, Kluyveromyces marxianus and Scheffersomyces stipitis, cultivated under glucose excess conditions. Combining physiological and proteome quantification with genome-scale metabolic modeling, we found that the two groups differ in energy metabolism and translation efficiency. In Crabtree-positive yeasts, the central carbon metabolism flux and proteome allocation favor a glucose utilization strategy minimizing proteome cost as proteins translation parameters, including ribosomal content and/or efficiency, are lower. Crabtree-negative yeasts, however, use a strategy of maximizing ATP yield, accompanied by higher protein translation parameters. Our analyses provide insight into the underlying reasons for the Crabtree effect, demonstrating a coupling to adaptations in both metabolism and protein translation.
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