Kinetic aspects of virus targeting by nanoparticles in vivo
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| Název: | Kinetic aspects of virus targeting by nanoparticles in vivo |
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| Autoři: | Zhdanov, Vladimir, 1952 |
| Zdroj: | Journal of Biological Physics. 47(2):95-101 |
| Témata: | Kinetic model, Nanoparticles, Inhibition, Viral infection, Association |
| Popis: | One of the suggested ways of the use of nanoparticles in virology implies their association with and subsequent deactivation of virions. The conditions determining the efficiency of this approach in vivo are now not clear. Herein, I propose the first kinetic model describing the corresponding processes and clarifying these conditions. My analysis indicates that nanoparticles can decrease concentration of infected cells by a factor of one order of magnitude, but this decrease itself (without feedback of the immune system) is insufficient for full eradication of infection. It can, however, induce delay in the progress of infection, and this delay can help to form sufficient feedback of the immune system. |
| Popis souboru: | electronic |
| Přístupová URL adresa: | https://research.chalmers.se/publication/524400 https://research.chalmers.se/publication/524501 https://research.chalmers.se/publication/524501/file/524501_Fulltext.pdf |
| Databáze: | SwePub |
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Nájsť tento článok vo Web of Science | Abstrakt: | One of the suggested ways of the use of nanoparticles in virology implies their association with and subsequent deactivation of virions. The conditions determining the efficiency of this approach in vivo are now not clear. Herein, I propose the first kinetic model describing the corresponding processes and clarifying these conditions. My analysis indicates that nanoparticles can decrease concentration of infected cells by a factor of one order of magnitude, but this decrease itself (without feedback of the immune system) is insufficient for full eradication of infection. It can, however, induce delay in the progress of infection, and this delay can help to form sufficient feedback of the immune system. |
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| ISSN: | 00920606 15730689 |
| DOI: | 10.1007/s10867-021-09570-z |