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Two photoacoustic spectral coloring compensation techniques adapted to the context of human in-vivo oxygenation measurements

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Názov: Two photoacoustic spectral coloring compensation techniques adapted to the context of human in-vivo oxygenation measurements
Autori: Khodaverdi, Azin, Jayet, Baptiste, Erlöv, Tobias, Albinsson, John, Merdasa, Aboma, Gustafsson, Nils, Sheikh, Rafi, Malmsjö, Malin, Andersson-Engels, Stefan, Cinthio, Magnus
Prispievatelia: Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Light and Materials, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Ljus och material, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator, Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Biomedical Engineering, Division for Biomedical Engineering, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för biomedicinsk teknik, Avdelningen för biomedicinsk teknik, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Photon Science and Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Avancerade ljuskällor, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Ophthalmology, Lund, Ophthalmology Imaging Research Group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Oftalmologi, Lund, Forskargruppen för oftalmologisk avbildning, Originator, Lund University, Faculty of Science, Department of Physics, Solid State Physics, Lunds universitet, Naturvetenskapliga fakulteten, Fysiska institutionen, Fasta tillståndets fysik, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Nanoscience and Semiconductor Technology, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Nanovetenskap och halvledarteknologi, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), NanoLund: Centre for Nanoscience, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), NanoLund: Centre for Nanoscience, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Thoracic Surgery, Clinical and experimental lung transplantation, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Thoraxkirurgi, Klinisk och experimentell lungtransplantation, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Thoracic Surgery, NPWT technology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Thoraxkirurgi, NPWT teknologin, Originator
Zdroj: Biomedical Optics Express Development of Photoacoustic Imaging Techniques Towards Clinical Translation. 16(6):2217-2231
Predmety: Engineering and Technology, Medical Engineering, Medical Laboratory Technologies, Teknik, Medicinteknik, Medicinsk laboratorieteknik, Medical and Health Sciences, Clinical Medicine, Ophthalmology, Medicin och hälsovetenskap, Klinisk medicin, Oftalmologi
Popis: Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation on in-vivo human data. Both methods have been modified and adapted to this context. The first modified method was evaluated using a tissue-mimicking phantom, showing restoration of the original spectrum of the target and decreasing the relative mean square error from 65% to 1.2% for the highest concentration. Spatial maps of sO2 were estimated from in-vivo human finger measurements using both methods and compared with linear unmixing. Both methods reconstructed comparable values of sO2 and reduced depth-dependent changes in sO2, typically seen with linear unmixing, resulting in a gradient of saturation closer to zero as expected physiologically.
Prístupová URL adresa: https://doi.org/10.1364/BOE.555305
Databáza: SwePub
Popis
Abstrakt:Photoacoustic imaging can potentially map oxygen saturation (sO2) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of chromophore concentrations deep in tissue. This study compares the performances of two previously proposed methods for spectral coloring compensation on in-vivo human data. Both methods have been modified and adapted to this context. The first modified method was evaluated using a tissue-mimicking phantom, showing restoration of the original spectrum of the target and decreasing the relative mean square error from 65% to 1.2% for the highest concentration. Spatial maps of sO2 were estimated from in-vivo human finger measurements using both methods and compared with linear unmixing. Both methods reconstructed comparable values of sO2 and reduced depth-dependent changes in sO2, typically seen with linear unmixing, resulting in a gradient of saturation closer to zero as expected physiologically.
ISSN:21567085
DOI:10.1364/BOE.555305