Diffusion MRI in the cortex of the brain: Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding
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| Titel: | Diffusion MRI in the cortex of the brain: Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding |
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| Autoren: | Säll, Cornelia, Spotorno, Nicola, Sundgren, Pia C., van Westen, Danielle, Westin, Carl Fredrik, Szczepankiewicz, Filip, Nilsson, Markus |
| Weitere Verfasser: | Lund University, Faculty of Science, Medical Radiation Physics, Lund, Lunds universitet, Naturvetenskapliga fakulteten, Medicinsk strålningsfysik, Lund, Originator, Lund University, Faculty of Science, Medical Radiation Physics, Lund, MR Physics, Lunds universitet, Naturvetenskapliga fakulteten, Medicinsk strålningsfysik, Lund, MR Physics, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), eSSENCE: The e-Science Collaboration, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), eSSENCE: The e-Science Collaboration, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Clinical Memory Research, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Klinisk minnesforskning, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), MultiPark: Multidisciplinary research focused on Parkinson's disease, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), MultiPark: Multidisciplinary research focused on Parkinson's disease, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Proactive Ageing, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Proaktivt åldrande, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Originator, Lund University, Profile areas and other strong research environments, Other Strong Research Environments, LUCC: Lund University Cancer Centre, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Övriga starka forskningsmiljöer, LUCC: Lunds universitets cancercentrum, Originator, Lund University, Faculty of Medicine, Lund University Bioimaging Center, Lunds universitet, Medicinska fakulteten, Lund University Bioimaging Center, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Neuroradiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Neuroradiologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Multidimensional microstructure imaging, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Multidimensional microstructure imaging, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator |
| Quelle: | Magnetic Resonance in Medicine. 94(3):1166-1181 |
| Schlagwörter: | Medical and Health Sciences, Clinical Medicine, Radiology and Medical Imaging, Medicin och hälsovetenskap, Klinisk medicin, Radiologi och bildbehandling |
| Beschreibung: | Purpose: The mean diffusivity (MD) is sensitive to the microstructure of the cortex. However, partial volume effects with CSF and white matter (WM) may obscure pathology-related alterations. This work investigates both existing approaches and a novel approach for reducing partial volume effects. Theory and Methods: A bias in MD arises due to partial volume effects, higher-order terms, and the noise floor in magnitude data. We propose to reduce this bias by using high b-value encoding to limit partial volume effects with CSF, spherical b-tensor encoding to reduce the influence of higher-order terms, and super-resolution acquisition and reconstruction to suppress the noise floor. This approach was investigated, along with established approaches (inversion recovery and free water elimination) for reducing partial volume effects, using simulations and in vivo data. Results: High b-value diffusion MRI with spherical b-tensor encoding reduced partial volume effects with CSF relative to conventional diffusion MRI. Maximum errors decreased from 0.51 to 0.01 μm2/ms in simulations. In vivo, the median absolute deviation of cortical MD decreased from 0.17 to 0.06 μm2/ms, whereas the median decreased slightly from 0.77 to 0.73 μm2/ms. The other methods yielded bias from either CSF, WM, or model assumptions. Conclusion: The mean diffusivity of the cortex can be mapped in high precision with reduced influence of partial volume effects with CSF and WM matter using high b-values and spherical b-tensor encoding and super-resolution reconstruction. |
| Zugangs-URL: | https://doi.org/10.1002/mrm.30552 |
| Datenbank: | SwePub |
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Nájsť tento článok vo Web of Science | Abstract: | Purpose: The mean diffusivity (MD) is sensitive to the microstructure of the cortex. However, partial volume effects with CSF and white matter (WM) may obscure pathology-related alterations. This work investigates both existing approaches and a novel approach for reducing partial volume effects. Theory and Methods: A bias in MD arises due to partial volume effects, higher-order terms, and the noise floor in magnitude data. We propose to reduce this bias by using high b-value encoding to limit partial volume effects with CSF, spherical b-tensor encoding to reduce the influence of higher-order terms, and super-resolution acquisition and reconstruction to suppress the noise floor. This approach was investigated, along with established approaches (inversion recovery and free water elimination) for reducing partial volume effects, using simulations and in vivo data. Results: High b-value diffusion MRI with spherical b-tensor encoding reduced partial volume effects with CSF relative to conventional diffusion MRI. Maximum errors decreased from 0.51 to 0.01 μm2/ms in simulations. In vivo, the median absolute deviation of cortical MD decreased from 0.17 to 0.06 μm2/ms, whereas the median decreased slightly from 0.77 to 0.73 μm2/ms. The other methods yielded bias from either CSF, WM, or model assumptions. Conclusion: The mean diffusivity of the cortex can be mapped in high precision with reduced influence of partial volume effects with CSF and WM matter using high b-values and spherical b-tensor encoding and super-resolution reconstruction. |
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| ISSN: | 07403194 15222594 |
| DOI: | 10.1002/mrm.30552 |