Predicting blink rate and pupil diameter from ADHD symptoms: Effects of white noise stimulation in an experimental study
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| Titel: | Predicting blink rate and pupil diameter from ADHD symptoms: Effects of white noise stimulation in an experimental study |
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| Autoren: | Jostrup, Erica, Claesdotter-Knutsson, Emma, Tallberg, Pia, Söderlund, Göran, Gustafsson, Peik, Nyström, Marcus |
| Weitere Verfasser: | Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Child and Adolescent Psychiatry, Innovations in pediatric mental health, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Barn- och ungdomspsykiatri, Innovations in pediatric mental health, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Child and Adolescent Psychiatry, Child and Adolescent Psychiatric Conditions and Associated Risk Factors: CARE, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Barn- och ungdomspsykiatri, Barn- och ungdomspsykiatriska tillstånd och associerade riskfaktorer, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Child and Adolescent Psychiatry, LUNDD (LUnd Neurodevelopmental Disorders), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Barn- och ungdomspsykiatri, Klinisk barn och ungdomspsykiatri, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Child and Adolescent Psychiatry, Evidence based clinical methods, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Barn- och ungdomspsykiatri, Evidensbaserade kliniska metoder, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Natural and Artificial Cognition, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Naturlig och artificiell kognition, Originator, Lund University, Joint Faculties of Humanities and Theology, Units, Lund University Humanities Lab, Lunds universitet, Humanistiska och teologiska fakulteterna, Fakultetsgemensamma verksamheter, Humanistlaboratoriet, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), eSSENCE: The e-Science Collaboration, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), eSSENCE: The e-Science Collaboration, Originator |
| Quelle: | Brain Disorders. 20:1-9 |
| Schlagwörter: | Medical and Health Sciences, Clinical Medicine, Psychiatry, Medicin och hälsovetenskap, Klinisk medicin, Psykiatri |
| Beschreibung: | Background Children with ADHD are reported to have lower dopamine (DA) and norepinephrine (NE) levels compared to typically developing children. We exploratively investigated how blink rate and pupil diameter, which are considered to be proxies for DA and NE signaling, were related to ADHD symptom severity. Moreover, we tested whether this relation is modulated by auditory white noise stimulation, which has been suggested as a non-pharmacological treatment for children with ADHD. Method We measured blink rate and pupil diameter in 97 children with varying levels of ADHD symptoms during a 60 s fixation task. The task was performed with and without auditory white noise stimulation. The effect of white noise stimulation was evaluated in relation to symptom severity and task duration. Results We found no relationship between the level of ADHD symptom severity and blink rate or pupil diameter, nor did symptom severity interact with auditory white noise stimulation. However, pupil diameter was consistently larger throughout the entire task as a result of the noise stimulation, an effect driven by boys. Conclusions Blink rate and pupil diameter do not seem to be reliably associated with ADHD symptom severity. This association also did not change when applying white noise stimulation. However, given the larger pupil diameter of boys, sex should be considered in future studies using white noise stimulation. |
| Zugangs-URL: | https://doi.org/10.1016/j.dscb.2025.100289 |
| Datenbank: | SwePub |
Nájsť tento článok vo Web of Science | Abstract: | Background Children with ADHD are reported to have lower dopamine (DA) and norepinephrine (NE) levels compared to typically developing children. We exploratively investigated how blink rate and pupil diameter, which are considered to be proxies for DA and NE signaling, were related to ADHD symptom severity. Moreover, we tested whether this relation is modulated by auditory white noise stimulation, which has been suggested as a non-pharmacological treatment for children with ADHD. Method We measured blink rate and pupil diameter in 97 children with varying levels of ADHD symptoms during a 60 s fixation task. The task was performed with and without auditory white noise stimulation. The effect of white noise stimulation was evaluated in relation to symptom severity and task duration. Results We found no relationship between the level of ADHD symptom severity and blink rate or pupil diameter, nor did symptom severity interact with auditory white noise stimulation. However, pupil diameter was consistently larger throughout the entire task as a result of the noise stimulation, an effect driven by boys. Conclusions Blink rate and pupil diameter do not seem to be reliably associated with ADHD symptom severity. This association also did not change when applying white noise stimulation. However, given the larger pupil diameter of boys, sex should be considered in future studies using white noise stimulation. |
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| DOI: | 10.1016/j.dscb.2025.100289 |