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Association between injury-related factors and cartilage T2 relaxation time in the subacute phase in patients after anterior cruciate ligament injury

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Titel: Association between injury-related factors and cartilage T2 relaxation time in the subacute phase in patients after anterior cruciate ligament injury
Autoren: Tajik, Bashir Edwardsson, Kvist, Joanna, Gauffin, Håkan, Cristiani, Riccardo, Frobell, Richard, Nieminen, Miika, Casula, Victor, Englund, Martin
Weitere Verfasser: Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Lund OsteoArthritis Division - Joint injury research group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Lund OsteoArthritis Division - Joint injury research group, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Originator, Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Proactive Ageing, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Proaktivt åldrande, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section III, Orthopaedics (Lund), Lund OsteoArthritis Division - Clinical Epidemiology Unit, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion III, Ortopedi, Lund, Lund OsteoArthritis Division - Clinical Epidemiology Unit, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator
Quelle: Osteoarthritis and Cartilage. 33(8):1033-1040
Schlagwörter: Medical and Health Sciences, Clinical Medicine, Orthopaedics, Medicin och hälsovetenskap, Klinisk medicin, Ortopedi
Beschreibung: OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury. DESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs were determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage was performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest. RESULTS: There was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading. CONCLUSION: In the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.
Zugangs-URL: https://doi.org/10.1016/j.joca.2025.05.002
Datenbank: SwePub
Beschreibung
Abstract:OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury. DESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs were determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage was performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest. RESULTS: There was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading. CONCLUSION: In the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.
ISSN:10634584
15229653
DOI:10.1016/j.joca.2025.05.002