| Prispievatelia: |
Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Orthopedics, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Ortopedi, Originator, Lund University, Faculty of Medicine, Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Lunds universitet, Medicinska fakulteten, Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi och farmakologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Infect@LU, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Infect@LU, Originator, Lund University, Faculty of Medicine, Department of Translational Medicine, Clinical Chemistry, Malmö, Lunds universitet, Medicinska fakulteten, Institutionen för translationell medicin, Klinisk kemi, Malmö, Originator |
| Popis: |
INTRODUCTION: The gold standard for monitoring long-term glucose levels in patients with diabetes mellitus is glycated hemoglobin (HbA1c). In conditions where the erythrocyte half-life is decreased, for example, in long-term kidney diseases and hemoglobinopathies, HbA1C may underestimate the long-term glucose exposure. Therefore, in these patient groups, other methods to monitor long-term glucose have been suggested, including glycated serum protein (GSP). To further optimize the method, a correction against total serum albumin has been proposed, defined as a percentage of glycated albumin (%GA). The aim of this study was to investigate the correlation between HbA1c, GSP, and %GA-a strong correlation to HbA1c would strengthen the potential usefulness of GSP and %GA as alternative methods to monitor glucose exposure in certain patient populations. METHODS: In this study, randomly collected human samples (n = 271), with different levels of HbA1c were analyzed for GSP and total serum albumin and a %GA was calculated. We also divided the samples into subgroups based on their HbA1c-result, age, and gender. RESULTS: Both %GA and GSP were strongly correlated with HbA1c, where %GA displayed the strongest correlation (R2 0.77 compared with R2 0.66.). When dividing into subgroups based on HbA1c-results, statistically significant differences in %GA were observed between all the different subgroups. CONCLUSION: In conclusion, the findings of this study strengthen the possibility of using GSP and %GA as possible alternatives or at least a supplement to HbA1c for monitoring long-term glucose exposure. Theoretically, particularly %GA could have the potential to supplement HbA1C in patients where the erythrocyte half-life is altered. |
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