24 h severe fluid restriction increases a biomarker of renal injury in healthy males
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| Název: | 24 h severe fluid restriction increases a biomarker of renal injury in healthy males |
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| Autoři: | Juett, Loris A., Funnell, Mark P., Carroll, Harriet A., James, Lewis J., Mears, Stephen A. |
| Přispěvatelé: | Lund University, Faculty of Medicine, Department of Clinical Sciences, Malmö, Cardiovascular Research - Hypertension, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Malmö, Kardiovaskulär forskning - hypertoni, Originator |
| Zdroj: | European Journal of Applied Physiology. 125(7):1983-1995 |
| Témata: | Medical and Health Sciences, Health Sciences, Nutrition and Dietetics, Medicin och hälsovetenskap, Hälsovetenskap, Näringslära och dietkunskap |
| Popis: | Purpose: Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance. Methods: Fifteen males (age: 27 ± 5 y; BMI: 24.1 ± 3.8 kg/m2) completed two randomised trials, involving consuming either 40 mL/kg body mass water to maintain euhydration (EU) or severe fluid restriction via limiting water consumption to 100 mL (HYP). A standardised dry food diet was consumed in both trials (~ 300 g water). At baseline and 24 h post-baseline, nude body mass, and blood and urine samples (additional urine sample at 12 h) were collected. An oral glucose tolerance test was conducted after 24-h post-baseline measurements (n = 12). Results: At 24 h, body mass loss (HYP: − 1.52 ± 0.34%, EU: − 0.24 ± 0.40%), plasma volume loss, serum, and urine osmolality were greater in HYP than EU (P ≤ 0.004). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were greater in HYP at 12 (HYP: 1.097 ± 0.587 ng/mOsm, EU: 0.570 ± 0.408 ng/mOsm; P < 0.001) and 24-h (HYP: 1.932 ± 1.173 ng/mOsm, EU: 1.599 ± 1.012 ng/mOsm; P = 0.01). There was no trial-by-time interactions for osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (P = 0.781) or plasma glucose (P = 0.550) and insulin (P = 0.193) concentrations. Conclusion: Hypohydration produced by 24-h fluid restriction increased proximal tubular injury but did not affect glucose tolerance. |
| Přístupová URL adresa: | https://doi.org/10.1007/s00421-025-05749-7 |
| Databáze: | SwePub |
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Nájsť tento článok vo Web of Science | Abstrakt: | Purpose: Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance. Methods: Fifteen males (age: 27 ± 5 y; BMI: 24.1 ± 3.8 kg/m2) completed two randomised trials, involving consuming either 40 mL/kg body mass water to maintain euhydration (EU) or severe fluid restriction via limiting water consumption to 100 mL (HYP). A standardised dry food diet was consumed in both trials (~ 300 g water). At baseline and 24 h post-baseline, nude body mass, and blood and urine samples (additional urine sample at 12 h) were collected. An oral glucose tolerance test was conducted after 24-h post-baseline measurements (n = 12). Results: At 24 h, body mass loss (HYP: − 1.52 ± 0.34%, EU: − 0.24 ± 0.40%), plasma volume loss, serum, and urine osmolality were greater in HYP than EU (P ≤ 0.004). Osmolality-corrected urinary kidney injury molecule-1 (uKIM-1) concentrations were greater in HYP at 12 (HYP: 1.097 ± 0.587 ng/mOsm, EU: 0.570 ± 0.408 ng/mOsm; P < 0.001) and 24-h (HYP: 1.932 ± 1.173 ng/mOsm, EU: 1.599 ± 1.012 ng/mOsm; P = 0.01). There was no trial-by-time interactions for osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (P = 0.781) or plasma glucose (P = 0.550) and insulin (P = 0.193) concentrations. Conclusion: Hypohydration produced by 24-h fluid restriction increased proximal tubular injury but did not affect glucose tolerance. |
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| ISSN: | 14396319 14396327 |
| DOI: | 10.1007/s00421-025-05749-7 |