Ex Vivo Working Porcine Heart Model
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| Název: | Ex Vivo Working Porcine Heart Model |
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| Autoři: | Pigot, Harry, Soltesz, Kristian, Steen, Stig |
| Přispěvatelé: | Lund University, Profile areas and other strong research environments, Lund University Profile areas, LU Profile Area: Natural and Artificial Cognition, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Lunds universitets profilområden, LU profilområde: Naturlig och artificiell kognition, Originator, Lund University, Faculty of Medicine, Department of Translational Medicine, Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS), Lunds universitet, Medicinska fakulteten, Institutionen för translationell medicin, Artificiell intelligens och bioinformatik inom thoraxkirurgisk vetenskap, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: AI and Digitalization, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: AI och digitalisering, Originator, Lund University, Faculty of Engineering, LTH, LTH Profile areas, LTH Profile Area: Engineering Health, Lunds universitet, Lunds Tekniska Högskola, LTH profilområden, LTH profilområde: Teknik för hälsa, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), ELLIIT: the Linköping-Lund initiative on IT and mobile communication, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), ELLIIT: the Linköping-Lund initiative on IT and mobile communication, Originator, Lund University, Faculty of Engineering, LTH, Departments at LTH, Department of Automatic Control, Lunds universitet, Lunds Tekniska Högskola, Institutioner vid LTH, Institutionen för reglerteknik, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Thoracic Surgery, Heart and Lung transplantation, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Thoraxkirurgi, Hjärt- och lungtransplantation, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section II, Thoracic Surgery, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion II, Thoraxkirurgi, Originator |
| Zdroj: | Experimental Models of Cardiovascular Diseases Methods in Molecular Biology Afterload system design for functional donor heart assessment. 2803(2):87-107 |
| Témata: | Engineering and Technology, Medical Engineering, Medical Instrumentation (including Measurement Technologies), Teknik, Medicinteknik, Medicinsk instrumentering (Här ingår: Mätteknik), Medical and Health Sciences, Medical Biotechnology, Medicin och hälsovetenskap, Medicinsk bioteknologi, Clinical Medicine, Cardiology and Cardiovascular Disease, Klinisk medicin, Kardiologi och kardiovaskulära sjukdomar, Electrical Engineering, Electronic Engineering, Information Engineering, Control Engineering, Elektroteknik och elektronik, Reglerteknik |
| Popis: | Ex vivo working porcine heart models allow for the study of a heart’s function and physiology outside the living organism. These models are particularly useful due to the anatomical and physiological similarities between porcine and human hearts, providing an experimental platform to investigate cardiac disease or assess donor heart viability for transplantation. This chapter presents an in-depth discussion of the model’s components, including the perfusate, preload, and afterload. We explore the challenges of emulating cardiac afterload and present a historical perspective on afterload modeling, discussing various methodologies and their respective limitations. An actively controlled afterload device is introduced to enhance the model’s ability to rapidly adjust pressure in the large arteries, thereby providing a more accurate and dynamic experimental model. Finally, we provide a comprehensive experimental protocol for the ex vivo working porcine heart model. |
| Přístupová URL adresa: | https://doi.org/10.1007/978-1-0716-3846-0_7 |
| Databáze: | SwePub |
Nájsť tento článok vo Web of Science | Abstrakt: | Ex vivo working porcine heart models allow for the study of a heart’s function and physiology outside the living organism. These models are particularly useful due to the anatomical and physiological similarities between porcine and human hearts, providing an experimental platform to investigate cardiac disease or assess donor heart viability for transplantation. This chapter presents an in-depth discussion of the model’s components, including the perfusate, preload, and afterload. We explore the challenges of emulating cardiac afterload and present a historical perspective on afterload modeling, discussing various methodologies and their respective limitations. An actively controlled afterload device is introduced to enhance the model’s ability to rapidly adjust pressure in the large arteries, thereby providing a more accurate and dynamic experimental model. Finally, we provide a comprehensive experimental protocol for the ex vivo working porcine heart model. |
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| ISSN: | 10643745 19406029 |
| DOI: | 10.1007/978-1-0716-3846-0_7 |