Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin
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| Title: | Brain health: Pathway to primary prevention of neurodegenerative disorders of environmental origin |
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| Authors: | Spencer, Peter S., Berntsson, Shala, 1964, Buguet, Alain, Butterfield, Patricia, Calne, Donald B., Calne, Susan M., Gimenez-Roldan, Santiago, Hugon, Jacques, Kahlon, Sahiba, Kisby, Glen E., Lagrange, Emmeline, Landtblom, Anne-Marie, Ludolph, Albert C., Nunn, Peter B., Palmer, Valerie S., Reis, Jacques, Roman, Gustavo C., Sipila, Jussi O. T., Spencer, Scott S., Angues, Raquel Valdes, Vernoux, Jean-Paul, Yabushita, Momoko |
| Source: | Journal of the Neurological Sciences. 468 |
| Subject Terms: | Amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, Disease clusters, Lifetime exposome |
| Description: | While rising global rates of neurodegenerative disease encourage early diagnosis and therapeutic intervention to block clinical expression (secondary prevention), a more powerful approach is to identify and remove environmental factors that trigger long-latencybrain disease (primary prevention) by acting on a susceptible genotype or acting alone. The latter is illustrated by the post-World War II decline and disappearance of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex (ALS/PDC), a prototypical often-familial neurodegenerative disease formerly present in very high incidence on the island of Guam. Lessons learned from 75 years of investigation on the etiology of ALS/PDC include: the importance of focusing field research on the disease epicenter and patients with early-onset disease; soliciting exposure history from patients, family, and community to guide multidisciplinary biomedical investigation; recognition that disease phenotype may vary with exposure history, and that familial brain disease may have a primarily environmental origin. Furthermore, removal from exposure to the environmental trigger effects primary disease prevention. |
| File Description: | electronic |
| Access URL: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-547327 https://uu.diva-portal.org/smash/get/diva2:1927844/FULLTEXT01.pdf |
| Database: | SwePub |
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Nájsť tento článok vo Web of Science | Abstract: | While rising global rates of neurodegenerative disease encourage early diagnosis and therapeutic intervention to block clinical expression (secondary prevention), a more powerful approach is to identify and remove environmental factors that trigger long-latencybrain disease (primary prevention) by acting on a susceptible genotype or acting alone. The latter is illustrated by the post-World War II decline and disappearance of Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex (ALS/PDC), a prototypical often-familial neurodegenerative disease formerly present in very high incidence on the island of Guam. Lessons learned from 75 years of investigation on the etiology of ALS/PDC include: the importance of focusing field research on the disease epicenter and patients with early-onset disease; soliciting exposure history from patients, family, and community to guide multidisciplinary biomedical investigation; recognition that disease phenotype may vary with exposure history, and that familial brain disease may have a primarily environmental origin. Furthermore, removal from exposure to the environmental trigger effects primary disease prevention. |
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| ISSN: | 0022510X 18785883 |
| DOI: | 10.1016/j.jns.2024.123340 |