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Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer’s disease: A longitudinal study of structural and functional MRI and MRS

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Názov: Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer’s disease: A longitudinal study of structural and functional MRI and MRS
Autori: Göschel, Laura, Dell’Orco, Andrea, Fillmer, Ariane, Aydin, Semiha, Ittermann, Bernd, Riemann, Layla, Lehmann, Sylvain, Cano, Stefan, Melin, Jeanette, Pendrill, Leslie, Hoede, Patty L., Teunissen, Charlotte E., Schwarz, Claudia, Grittner, Ulrike, Körtvélyessy, Péter, Flöel, Agnes
Zdroj: Alzheimer's & Dementia. 20(12):8684-8699
Predmety: Aged, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Brain, Disease Progression, Female, Glial Fibrillary Acidic Protein, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Middle Aged, Neurofilament Proteins, Phosphorylation, tau Proteins, amyloid beta protein[1-40], amyloid beta protein[1-42], glial fibrillary acidic protein, neurofilament protein, phosphoprotein, tau protein, threonine, amyloid beta protein, biological marker, GFAP protein, human, adult, aged, Alzheimer disease, Article, blood sampling, cognition, cohort analysis, controlled study, default mode network, disease exacerbation, executive function, female, functional magnetic resonance imaging, functional neuroimaging, hippocampus, image analysis, image segmentation, light chain, longitudinal study, male, Mini Mental State Examination, nervous system inflammation, neuroanatomy, neurofilament, neuroimaging, neurologic examination, neuropsychological assessment, nuclear magnetic resonance spectroscopy, parietal lobe, posterior cingulate, precuneus, protein blood level, salience network, T1 weighted imaging, trail making test, Wechsler adult intelligence scale, blood, brain, diagnostic imaging, middle aged, nuclear magnetic resonance imaging, pathology, phosphorylation
Popis: BACKGROUND: Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer’s disease (AD) remain unclear. METHODS: In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models. RESULTS: Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol. DISCUSSION: Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively. Highlights: This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer’s disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
Popis súboru: electronic
Prístupová URL adresa: https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-77798
https://doi.org/10.1002/alz.14318
Databáza: SwePub
Popis
Abstrakt:BACKGROUND: Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer’s disease (AD) remain unclear. METHODS: In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models. RESULTS: Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol. DISCUSSION: Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively. Highlights: This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer’s disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
ISSN:15525260
15525279
DOI:10.1002/alz.14318