The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study
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| Názov: | The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study |
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| Autori: | Carannante, Ilaria, Scolamiero, Martina, 1986, Hjorth, J. J. Johannes, Kozlov, Alexander, Bekkouche, Bo, Guo, Lihao, Kumar, Arvind, Chachólski, Wojciech, Hellgren Kotaleski, Jeanette |
| Zdroj: | Network Neuroscience. 8(4):1149-1172 |
| Predmety: | Parkinson's disease, Striatum, Computational modeling, Topological data analysis, Directed cliques, Network higher order connectivity, Neuronal degeneration model |
| Popis: | This in silico study predicts the impact that the single-cell neuronal morphological alterations will have on the striatal microcircuit connectivity. We find that the richness in the topological striatal motifs is significantly reduced in Parkinson's disease (PD), highlighting that just measuring the pairwise connectivity between neurons gives an incomplete description of network connectivity. Moreover, we predict how the resulting electrophysiological changes of striatal projection neuron excitability together with their reduced number of dendritic branches affect their response to the glutamatergic drive from the cortex and thalamus. We find that the effective glutamatergic drive is likely significantly increased in PD, in accordance with the hyperglutamatergic hypothesis. |
| Popis súboru: | |
| Prístupová URL adresa: | https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-359481 https://doi.org/10.1162/netn_a_00394 |
| Databáza: | SwePub |
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Nájsť tento článok vo Web of Science | Abstrakt: | This in silico study predicts the impact that the single-cell neuronal morphological alterations will have on the striatal microcircuit connectivity. We find that the richness in the topological striatal motifs is significantly reduced in Parkinson's disease (PD), highlighting that just measuring the pairwise connectivity between neurons gives an incomplete description of network connectivity. Moreover, we predict how the resulting electrophysiological changes of striatal projection neuron excitability together with their reduced number of dendritic branches affect their response to the glutamatergic drive from the cortex and thalamus. We find that the effective glutamatergic drive is likely significantly increased in PD, in accordance with the hyperglutamatergic hypothesis. |
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| ISSN: | 24721751 |
| DOI: | 10.1162/netn_a_00394 |