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Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

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Název: Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
Autoři: Mok, Yejin, Surapaneni, Aditya, Sang, Yingying, Coresh, Josef, Grams, Morgan E, Matsushita, Kunihiro, Ballew, Shoshana H, Alencar de Pinho, Natalia, Ärnlöv, Johan, 1970, Barreto, Sandhi M, Bell, Samira, Brenner, Hermann, Carrero, Juan-Jesus, Chinnadurai, Rajkumar, Ciemins, Elizabeth, Gansevoort, Ron T, Jassal, Simerjot K, Jung, Keum Ji, Kirchner, H Lester, Konta, Tsuneo, Kovesdy, Csaba P, Luo, Li, Pandit, Krutika, Rahman, Mahboob, Robinson-Cohen, Cassianne, Sabanayagam, Charumathi, Schultheiss, Ulla T, Shlipak, Michael, Staplin, Natalie, Tonelli, Marcello, Wang, Angela Yee-Moon, Wen, Chi-Pang, Woodward, Mark, Lees, Jennifer S
Zdroj: British Journal of Cancer. 133(10):1535-1543
Popis: BACKGROUND: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.METHODS: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.RESULTS: Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis.DISCUSSION: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.
Popis souboru: electronic
Přístupová URL adresa: https://urn.kb.se/resolve?urn=urn:nbn:se:du-51343
https://doi.org/10.1038/s41416-025-03140-z
Databáze: SwePub
Popis
Abstrakt:<strong>BACKGROUND:</strong> Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.<strong>METHODS:</strong> This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.<strong>RESULTS:</strong> Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06-1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis.<strong>DISCUSSION:</strong> Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.
ISSN:00070920
15321827
DOI:10.1038/s41416-025-03140-z