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Biomaterials for enhanced implant-host integration

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Názov: Biomaterials for enhanced implant-host integration
Patent Number: 11617,817
Dátum vydania: April 04, 2023
Appl. No: 16/589768
Application Filed: October 01, 2019
Abstrakt: The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.
Inventors: The Trustees of the University of Pennsylvania (Philadelphia, PA, US); Massachusetts Institute of Technology (Cambridge, MA, US)
Assignees: The Trustees of the University of Pennsylvania (Philadelphia, PA, US), Massachusetts Institute of Technology (Cambridge, MA, US)
Claim: 1. A patterned biomaterial for implantation in a subject comprising at least one cord, formed by embedding cells in a naturally-derived or synthetic scaffolding with a pre-specified architecture and spatially organizing the cells within the scaffolding, wherein the at least one cord comprises endothelial cells, wherein the structure of the patterned biomaterial has a pre-specified architecture that acts as a template and spatial guidance for a subject's vasculature to invade and integrate at least partially within the at least one cord upon implantation.
Claim: 2. The patterned biomaterial of claim 1 , further comprising an extracellular matrix or a physically solid scaffold at least partially encapsulating the at least one cord.
Claim: 3. The patterned biomaterial of claim 2 , wherein the extracellular matrix scaffold comprises fibrin.
Claim: 4. The patterned biomaterial of claim 2 , wherein the extracellular matrix scaffold further comprises at least one cell type.
Claim: 5. The patterned biomaterial of claim 4 , wherein the at least one cell type comprises hepatocytes, endothelial cells, mesenchymal stem cells, or a combination thereof.
Claim: 6. The patterned biomaterial of claim 4 , wherein the at least one cell type comprises endothelial cells.
Claim: 7. The patterned biomaterial of claim 1 , wherein the naturally-derived or synthetic scaffolding comprises collagen.
Claim: 8. The patterned biomaterial of claim 1 , wherein the at least one chord is branched.
Claim: 9. The patterned biomaterial of claim 1 , wherein the at least one chord comprises a plurality of chords.
Claim: 10. The patterned biomaterial of claim 9 , wherein the plurality of cords are formed in a parallel arrangement within the naturally-derived or synthetic scaffolding.
Claim: 11. The patterned biomaterial of claim 9 , wherein the plurality of cords are formed in a nonparallel arrangement within the naturally-derived or synthetic scaffolding.
Claim: 12. The patterned biomaterial of claim 1 , wherein the at least one cord is cylindrical, Y-shaped, or T-shaped.
Claim: 13. The patterned biomaterial of claim 1 , wherein the at least one cord is solid or hollow in cross-section.
Claim: 14. The patterned biomaterial of claim 1 , further comprising at least one cluster of cells.
Claim: 15. The patterned biomaterial of claim 14 , wherein the at least one cluster of cells comprises hepatocytes, endothelial cells, mesenchymal stem cells, or a combination thereof.
Claim: 16. An ex vivo patterned biomaterial for implantation in a subject, comprising one or more endothelial cell cords, wherein the one or more cords is at least partially embedded in a naturally-derived or synthetic scaffolding, wherein the structure of the patterned biomaterial has a pre-specified architecture that acts as a template and spatial guidance for a subject's vasculature to invade and integrate at least partially within the one or more endothelial cell cords upon implantation.
Claim: 17. The ex vivo patterned biomaterial of claim 16 , wherein the scaffolding is a naturally-derived scaffolding.
Claim: 18. The ex vivo patterned biomaterial of claim 16 , wherein the scaffolding is a synthetic scaffolding.
Claim: 19. A patterned biomaterial post-implantation in a subject, comprising one or more endothelial cell cords, wherein the one or more cords is at least partially embedded in a naturally-derived or synthetic scaffolding, and wherein the subject's vasculature has invaded and integrated at least partially within the one or more endothelial cell cords.
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Primary Examiner: Johnson, Kara D
Attorney, Agent or Firm: McCarter & English, LLP
Prístupové číslo: edspgr.11617817
Databáza: USPTO Patent Grants
Popis
Abstrakt:The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.