Methods and compositions for improving microvascular function, suppressing cyclooxygenase activity, reducing platelet aggregation and increasing levels of resveratrol in plasma
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| Titel: | Methods and compositions for improving microvascular function, suppressing cyclooxygenase activity, reducing platelet aggregation and increasing levels of resveratrol in plasma |
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| Patent Number: | 11241,396 |
| Publikationsdatum: | February 08, 2022 |
| Appl. No: | 14/924712 |
| Application Filed: | October 28, 2015 |
| Abstract: | Methods of increasing the plasma concentration of resveratrol in a mammal in need thereof by administering to a mammal in need thereof an effective amount of trans-resveratrol and arginine for a period of at least two weeks. |
| Inventors: | Kothari, Shil (Fairfeild, CA, US); Troxel, Gary (Fairfeild, CA, US) |
| Assignees: | Gateway Health Alliances, Inc. (Fairfield, CA, US) |
| Claim: | 1. A method of improving microvascular function of a mammal in need thereof, the method comprising: providing to a mammal in need of improved microvascular function 10 mg to 5000 mg daily of a resveratrol and arginine conjugate; wherein the resveratrol and arginine conjugate increases the RHI of the mammal from about 0.369 to about 0.685 within about one hour of providing resveratrol and arginine conjugate to the mammal. |
| Claim: | 2. The method according to claim 1 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 900 mg daily. |
| Claim: | 3. The method according to claim 1 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 500 mg daily. |
| Claim: | 4. A method comprising: providing a mammal in need of improved microvascular function 10 mg to 5000 mg daily of a resveratrol and arginine conjugate for a period of at least two weeks; wherein the resveratrol and arginine conjugate increases the RHI of the mammal from about 0.369 to about 0.685 within about one hour of providing resveratrol and arginine conjugate to the mammal. |
| Claim: | 5. The method according to claim 4 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 900 mg daily. |
| Claim: | 6. The method according to claim 4 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 500 mg daily. |
| Claim: | 7. A method comprising: administering to a mammal in need of improved microvascular function within about an hour 10 mg to 5000 mg daily of a resveratrol and arginine conjugate for a period of at least two weeks; wherein the resveratrol and arginine conjugate increases the FRHI of the mammal from about 0.326 to about 0.466 within about one hour of providing resveratrol and arginine conjugate to the mammal. |
| Claim: | 8. The method according to claim 7 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 900 mg daily. |
| Claim: | 9. The method according to claim 7 , wherein the effective amount of the resveratrol and arginine conjugate is 50 mg to 500 mg daily. |
| Patent References Cited: | 9067908 June 2015 Delaire WO 2007096078 August 2007 WO 2011104667 September 2011 |
| Other References: | Yar et al., “The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats”, 2011, Genet. Mol. Res., 10(4), pp. 2962-2975. cited by examiner Vallianou et al., “Resveratrol and Diabetes”, 2013, The Review of Diabetic Studies, 10(4), pp. 236-242. cited by examiner Dolinsky et al., “Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice”, 2013, Biochimica et Biophysica Acta, 1832(10), pp. 1723-1733. cited by examiner |
| Primary Examiner: | Tran, My-Chau T |
| Attorney, Agent or Firm: | Partners Law Group, Inc Hassid, Steve P. |
| Dokumentencode: | edspgr.11241396 |
| Datenbank: | USPTO Patent Grants |
| Abstract: | Methods of increasing the plasma concentration of resveratrol in a mammal in need thereof by administering to a mammal in need thereof an effective amount of trans-resveratrol and arginine for a period of at least two weeks. |
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