Antibody-dependent enhancement (ADE) in Covid-19 physiopathology, a cross-model single-cell RNA-seq perspective
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| Titel: | Antibody-dependent enhancement (ADE) in Covid-19 physiopathology, a cross-model single-cell RNA-seq perspective |
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| Autoren: | Olivier, Thibaut, Desmecht, Daniel |
| Quelle: | 10th European Meeting on Viral Zoonoses, Saint-Raphaël, France [FR], 23 - 26 September 2023 |
| Publikationsjahr: | 2023 |
| Schlagwörter: | FcγR, M1 macrophages, SARS-CoV-2, antibody-dependent enhancement, cytokine storm, interferons, Interferons, Cytokines, Animals, Chlorocebus aethiops, Single-Cell Gene Expression Analysis, Interferons/metabolism, Alveolar Epithelial Cells/metabolism, Cytokines/metabolism, Macrophages/metabolism, COVID-19/metabolism, Alveolar Epithelial Cells, COVID-19, Macrophages, Immunology and Allergy, Immunology, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale |
| Beschreibung: | Cytokine storm is considered a driving factor of COVID-19 severity. However, the triggering and resolution of this cytokine production as well as the linkbetween this phenomenon and infected cells is still poorly understood. Considering that M1 macrophages are specialized for pathogen killing and secrete pro-inflammatorycytokines as well as chemokines upon Ifn-γ activation, an assessment of their contributions in cytokine storms is necessary. Moreover, considering that Fc receptors forimmunoglobulin G (FcγR) expression was found to be stimulated by Ifn-γ in monocytes and macrophages and that FcγR markedly affect antigen uptake in macrophages,exploring the potential link between FcγR-mediated antibody-dependent infections of M1 macrophages and the surge of cytokine storms caused by SARS-CoV-2 infectionsconstitutes a promising avenue of research to explain the phenomenon of antibody-dependent enhancement (ADE). |
| Publikationsart: | conference poster not in proceedings http://purl.org/coar/resource_type/c_18co conferencePoster |
| Sprache: | English |
| Zugangs-URL: | https://orbi.uliege.be/handle/2268/307193 |
| Rights: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| Dokumentencode: | edsorb.307193 |
| Datenbank: | ORBi |
| Abstract: | Cytokine storm is considered a driving factor of COVID-19 severity. However, the triggering and resolution of this cytokine production as well as the linkbetween this phenomenon and infected cells is still poorly understood. Considering that M1 macrophages are specialized for pathogen killing and secrete pro-inflammatorycytokines as well as chemokines upon Ifn-γ activation, an assessment of their contributions in cytokine storms is necessary. Moreover, considering that Fc receptors forimmunoglobulin G (FcγR) expression was found to be stimulated by Ifn-γ in monocytes and macrophages and that FcγR markedly affect antigen uptake in macrophages,exploring the potential link between FcγR-mediated antibody-dependent infections of M1 macrophages and the surge of cytokine storms caused by SARS-CoV-2 infectionsconstitutes a promising avenue of research to explain the phenomenon of antibody-dependent enhancement (ADE). |
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