Ex Vivo Tools and Models in MASLD Research
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| Název: | Ex Vivo Tools and Models in MASLD Research |
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| Autoři: | Velliou, Rallia-Iliana Giannousi, Eirini Ralliou, Christiana Kassi, Eva Chatzigeorgiou, Antonios |
| Informace o vydavateli: | 2024-01-01 |
| Druh dokumentu: | Electronic Resource |
| Abstrakt: | Metabolic dysfunction-associated fatty liver disease (MASLD) presents a growing global health challenge with limited therapeutic choices. This review delves into the array of ex vivo tools and models utilized in MASLD research, encompassing liver-on-a-chip (LoC) systems, organoid-derived tissue-like structures, and human precision-cut liver slice (PCLS) systems. Given the urgent need to comprehend MASLD pathophysiology and identify novel therapeutic targets, this paper aims to shed light on the pivotal role of advanced ex vivo models in enhancing disease understanding and facilitating the development of potential therapies. Despite challenges posed by the elusive disease mechanism, these innovative methodologies offer promise in reducing the utilization of in vivo models for MASLD research while accelerating drug discovery and biomarker identification, thereby addressing critical unmet clinical needs. © 2024 by the authors. |
| Témata: | scientific_publication_article, Scientific publication - Journal Article |
| URL: | |
| Dostupnost: | Open access content. Open access content |
| Poznámka: | English |
| Other Numbers: | GRNKU oai:lib.uoa.gr:uoadl:3486069 uoadl:3486069 1523431514 |
| Přispívající zdroj: | NATIONAL & KAPODISTRIAN UNIV OF ATHENS From OAIster®, provided by the OCLC Cooperative. |
| Přístupové číslo: | edsoai.on1523431514 |
| Databáze: | OAIster |
Nájsť tento článok vo Web of Science | Abstrakt: | Metabolic dysfunction-associated fatty liver disease (MASLD) presents a growing global health challenge with limited therapeutic choices. This review delves into the array of ex vivo tools and models utilized in MASLD research, encompassing liver-on-a-chip (LoC) systems, organoid-derived tissue-like structures, and human precision-cut liver slice (PCLS) systems. Given the urgent need to comprehend MASLD pathophysiology and identify novel therapeutic targets, this paper aims to shed light on the pivotal role of advanced ex vivo models in enhancing disease understanding and facilitating the development of potential therapies. Despite challenges posed by the elusive disease mechanism, these innovative methodologies offer promise in reducing the utilization of in vivo models for MASLD research while accelerating drug discovery and biomarker identification, thereby addressing critical unmet clinical needs. © 2024 by the authors. |
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