Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population
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| Title: | Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population |
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| Authors: | Priskorn, L, Bang, A K, Nordkap, L, Krause, M, Mendiola, J, Jensen, T K, Juul, A, Skakkebaek, N E, Swan, S H, Jørgensen, N |
| Source: | Priskorn , L , Bang , A K , Nordkap , L , Krause , M , Mendiola , J , Jensen , T K , Juul , A , Skakkebaek , N E , Swan , S H & Jørgensen , N 2019 , ' Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population ' , Human reproduction (Oxford, England) , vol. 34 , no. 1 , pp. 12-24 . |
| Publisher Information: | 2019-01-01 |
| Document Type: | Electronic Resource |
| Abstract: | STUDY QUESTION: Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population?SUMMARY ANSWER: Short AGD measured from the anus to the base of scrotum (AGDAS) was associated with reduced sperm counts and morphology but not with sperm motility or reproductive hormones.WHAT IS KNOWN ALREADY: AGD is longer in males than in females. In rodents, AGD is a well-established and sensitive marker of disruption during the masculinization programming window in utero and it has been suggested to be so in humans as well. Therefore, the average AGD would be expected to be shorter in men with poor semen quality, which some studies have confirmed while others have not.STUDY DESIGN, SIZE, DURATION: This cross-sectional population-based study was of 1106 men included between 2012 and 2016.PARTICIPANTS/MATERIALS, SETTING, METHODS: Men from the general Danish population (median age 19 years), unselected with regard to fertility status and semen quality, delivered a semen sample, had a blood sample drawn, which was analyzed for concentrations of reproductive hormones, and answered a comprehensive questionnaire. They also had a physical examination performed including determination of AGD measured as the distance between anus and scrotum (AGDAS) and penis (AGDAP). Odds ratios (OR) and 95% CI were estimated for a man having abnormal semen parameters according to the World Health Organization's reference values or a low/high concentration of reproductive hormones (defined as the lowest or highest 10%) depending on AGD. AGD was categorized in four strata: ≤10th percentile, 10th-30th percentile, 30th-50th percentile and >50th percentile.MAIN RESULTS AND THE ROLE OF CHANCE: Men with the 10% shortest AGDAS had a more than doubled risk (OR: 2.19, 95% CI: 1.40-3.42) of being in the subfertile range for either sperm concentration (<15 million/mL) or sperm morphology (<4%) compared to men with AG |
| Index Terms: | Adult, Anal Canal/anatomy & histology, Anthropometry, Cross-Sectional Studies, Denmark, Estradiol/blood, Fertility/physiology, Follicle Stimulating Hormone/blood, Humans, Luteinizing Hormone/blood, Male, Penis/anatomy & histology, Scrotum/anatomy & histology, Self Report/statistics & numerical data, Semen/physiology, Sperm Count, Sperm Motility/physiology, Young Adult, article |
| Availability: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| Note: | English |
| Other Numbers: | DAV oai:pure.atira.dk:publications/ef9be560-8345-499f-944d-34bdfe2dbdfd https://curis.ku.dk/portal/da/publications/anogenital-distance-is-associated-with-semen-quality-but-not-reproductive-hormones-in-1106-young-men-from-the-general-population(ef9be560-8345-499f-944d-34bdfe2dbdfd).html https://doi.org/10.1093/humrep/dey326 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295959/pdf/dey326.pdf 1322737622 |
| Contributing Source: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| Accession Number: | edsoai.on1322737622 |
| Database: | OAIster |
Nájsť tento článok vo Web of Science | Abstract: | STUDY QUESTION: Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population?SUMMARY ANSWER: Short AGD measured from the anus to the base of scrotum (AGDAS) was associated with reduced sperm counts and morphology but not with sperm motility or reproductive hormones.WHAT IS KNOWN ALREADY: AGD is longer in males than in females. In rodents, AGD is a well-established and sensitive marker of disruption during the masculinization programming window in utero and it has been suggested to be so in humans as well. Therefore, the average AGD would be expected to be shorter in men with poor semen quality, which some studies have confirmed while others have not.STUDY DESIGN, SIZE, DURATION: This cross-sectional population-based study was of 1106 men included between 2012 and 2016.PARTICIPANTS/MATERIALS, SETTING, METHODS: Men from the general Danish population (median age 19 years), unselected with regard to fertility status and semen quality, delivered a semen sample, had a blood sample drawn, which was analyzed for concentrations of reproductive hormones, and answered a comprehensive questionnaire. They also had a physical examination performed including determination of AGD measured as the distance between anus and scrotum (AGDAS) and penis (AGDAP). Odds ratios (OR) and 95% CI were estimated for a man having abnormal semen parameters according to the World Health Organization's reference values or a low/high concentration of reproductive hormones (defined as the lowest or highest 10%) depending on AGD. AGD was categorized in four strata: ≤10th percentile, 10th-30th percentile, 30th-50th percentile and >50th percentile.MAIN RESULTS AND THE ROLE OF CHANCE: Men with the 10% shortest AGDAS had a more than doubled risk (OR: 2.19, 95% CI: 1.40-3.42) of being in the subfertile range for either sperm concentration (<15 million/mL) or sperm morphology (<4%) compared to men with AG |
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