The local and global geometry of trabecular bone
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| Titel: | The local and global geometry of trabecular bone |
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| Autoren: | Callens, S.J.P. (author), Tourolle né Betts, Duncan C. (author), Müller, Ralph (author), Zadpoor, A.A. (author) |
| Verlagsinformationen: | 2021 |
| Publikationsart: | Electronic Resource |
| Abstract: | The organization and shape of the microstructural elements of trabecular bone govern its physical properties, are implicated in bone disease, and serve as blueprints for biomaterial design. To devise fundamental structure-property relationships and design truly bone-mimicking biomaterials, it is essential to characterize trabecular bone structure from the perspective of geometry, the mathematical study of shape. Using micro-CT images from 70 donors at five different sites, we analyze the local and global geometry of human trabecular bone in detail, respectively by quantifying surface curvatures and Minkowski functionals. We find that curvature density maps provide distinct and sensitive shape fingerprints for bone from different sites. Contrary to a common assumption, these curvature maps also show that bone morphology does not approximate a minimal surface but exhibits a much more intricate curvature landscape. At the global (or integral) perspective, our Minkowski analysis illustrates that trabecular bone exhibits other types of anisotropy/ellipticity beyond interfacial orientation, and that anisotropy varies substantially within the trabecular structure. Moreover, we show that the Minkowski functionals unify several traditional morphometric indices. Our geometric approach to trabecular morphometry provides a fundamental language of shape that could be useful for bone failure prediction, understanding geometry-driven tissue growth, and the design of bone-mimicking tissue scaffolds. Statement of significance: The architecture of trabecular bone is key in determining bone properties, and is often a starting point for the design of bone-substitutes. Despite the substantial history of bone morphometry, a fundamental characterization of trabecular bone geometry is still lacking. Therefore, we introduce a robust framework to quantify local and global trabecular bone geometry, which we apply to hundreds of micro-CT scans. Our approach relies on quantifying surface cur Biomaterials & Tissue Biomechanics |
| Index Begriffe: | Anisotropy, Minkowski tensors, Morphometry, Surface curvature, Trabecular bone, journal article |
| DOI: | 10.1016.j.actbio.2021.06.013 |
| URL: | Acta Biomaterialia--1742-7061--10b0d015-3068-4ade-b406-0c38cf14cf85 |
| Verfügbarkeit: | Open access content. Open access content © 2021 S.J.P. Callens, Duncan C. Tourolle né Betts, Ralph Müller, A.A. Zadpoor |
| Anmerkung: | English |
| Other Numbers: | NLTUD oai:tudelft.nl:uuid:acfb9b49-18ad-4de4-a5b3-931ecc9366a2 doi:10.1016/j.actbio.2021.06.013 1267689110 |
| Originalquelle: | DELFT UNIV OF TECHNOL From OAIster®, provided by the OCLC Cooperative. |
| Dokumentencode: | edsoai.on1267689110 |
| Datenbank: | OAIster |
Nájsť tento článok vo Web of Science | Abstract: | The organization and shape of the microstructural elements of trabecular bone govern its physical properties, are implicated in bone disease, and serve as blueprints for biomaterial design. To devise fundamental structure-property relationships and design truly bone-mimicking biomaterials, it is essential to characterize trabecular bone structure from the perspective of geometry, the mathematical study of shape. Using micro-CT images from 70 donors at five different sites, we analyze the local and global geometry of human trabecular bone in detail, respectively by quantifying surface curvatures and Minkowski functionals. We find that curvature density maps provide distinct and sensitive shape fingerprints for bone from different sites. Contrary to a common assumption, these curvature maps also show that bone morphology does not approximate a minimal surface but exhibits a much more intricate curvature landscape. At the global (or integral) perspective, our Minkowski analysis illustrates that trabecular bone exhibits other types of anisotropy/ellipticity beyond interfacial orientation, and that anisotropy varies substantially within the trabecular structure. Moreover, we show that the Minkowski functionals unify several traditional morphometric indices. Our geometric approach to trabecular morphometry provides a fundamental language of shape that could be useful for bone failure prediction, understanding geometry-driven tissue growth, and the design of bone-mimicking tissue scaffolds. Statement of significance: The architecture of trabecular bone is key in determining bone properties, and is often a starting point for the design of bone-substitutes. Despite the substantial history of bone morphometry, a fundamental characterization of trabecular bone geometry is still lacking. Therefore, we introduce a robust framework to quantify local and global trabecular bone geometry, which we apply to hundreds of micro-CT scans. Our approach relies on quantifying surface cur<br />Biomaterials & Tissue Biomechanics |
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| DOI: | 10.1016.j.actbio.2021.06.013 |