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Target validation in silico : does the virtual patient cure the pharma pipeline?

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Bibliographic Details
Title: Target validation in silico : does the virtual patient cure the pharma pipeline?
Authors: Wynand, Alkema, Ton, Rullmann, Andrea, van Elsas, Data Science for Life Science & Health
Source: Expert Opinion on Therapeutic Targets. 10(5):635-638
Publisher Information: Ashley.
Publication Year: 2006
Subject Terms: computer simulation, drug delivery systems/methods, drug design, humans, phenotypes, reproducibility of results, technology, pharmaceutical/methods, biotechnologie
Description: Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the human setting frequently fails due to unforeseen toxicity and efficacy issues. Biosimulation addresses these issues by capturing the complex dynamics of interacting molecules and cells in mechanistic, predictive models. A central concept is that of the virtual patient, an encapsulation of a specific pathophysiological behaviour in a biosimulation model. The authors describe how virtual patients are being used in target identification, target validation and clinical development, and discuss challenges for the acceptance of biosimulation methods.
Document Type: article
Language: English
Access URL: https://research.hanze.nl/en/publications/b4493b1d-ec14-4785-abc3-97de76030935
Availability: http://www.hbo-kennisbank.nl/en/page/hborecord.view/?uploadId=hanzepure:oai:research.hanze.nl:publications/b4493b1d-ec14-4785-abc3-97de76030935
Accession Number: edshbo.hanzepure.oai.research.hanze.nl.publications.b4493b1d.ec14.4785.abc3.97de76030935
Database: HBO Kennisbank
Description
Abstract:Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the human setting frequently fails due to unforeseen toxicity and efficacy issues. Biosimulation addresses these issues by capturing the complex dynamics of interacting molecules and cells in mechanistic, predictive models. A central concept is that of the virtual patient, an encapsulation of a specific pathophysiological behaviour in a biosimulation model. The authors describe how virtual patients are being used in target identification, target validation and clinical development, and discuss challenges for the acceptance of biosimulation methods.