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Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization

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Titel: Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization
Autoren: Zhen Xiong, Qianqian Wang, Wanhong Li, Lijuan Huang, Jianing Zhang, Juanhua Zhu, Bingbing Xie, Shasha Wang, Haiqing Kuang, Xianchai Lin, Chunsik Lee, Anil Kumar, Xuri Li
Quelle: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Verlagsinformationen: Frontiers Media S.A., 2021.
Publikationsjahr: 2021
Bestand: LCC:Biology (General)
Schlagwörter: PDGF-D, C1qa, C3, macrophage polarization, inflammation, Biology (General), QH301-705.5
Beschreibung: Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.
Publikationsart: article
Dateibeschreibung: electronic resource
Sprache: English
ISSN: 2296-634X
Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.686886/full; https://doaj.org/toc/2296-634X
DOI: 10.3389/fcell.2021.686886
Zugangs-URL: https://doaj.org/article/fdd7bafee10c4caf98043f7887a528b2
Dokumentencode: edsdoj.fdd7bafee10c4caf98043f7887a528b2
Datenbank: Directory of Open Access Journals
Beschreibung
Abstract:Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Pharmacological targeting of the complement C3a receptor using SB290157 alleviated PDGF-D-induced neuroinflammation by blocking macrophage polarization and inhibited pathological choroidal neovascularization. Our study thus suggests that therapeutic strategies targeting both PDGF-D and the complement system may open up new possibilities for the treatment of neovascular diseases.
ISSN:2296634X
DOI:10.3389/fcell.2021.686886