Relationship between brain-derived neurotrophic factor and mild to moderate cognitive impairment in the older Mexican population
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| Title: | Relationship between brain-derived neurotrophic factor and mild to moderate cognitive impairment in the older Mexican population |
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| Authors: | E. Rico-Fernández, C.A. Reyes-Hernandez, M.P. Rico-Fernández, F.J. García-Alvarado, H.A. Delgado-Aguirre |
| Source: | Neurology Perspectives, Vol 4, Iss 3, Pp 100158- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Deterioro cognitivo, Factor neurotrófico derivado del cerebro BDNF, Neurology. Diseases of the nervous system, RC346-429 |
| Description: | Background: Mild–moderate cognitive impairment is a frequent pathology in the adult population. It is important to explore early expression biomarkers that contribute to early detection and benefit the prognostic outlook. Brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, neuronal survival, and differentiation, and even a critical molecular target for drug development in neurological disorders. It is crucial to carry out studies in the early stages that better clarify the landscape of BDNF. Objective: To compare the serum levels of BDNF in healthy adult patients and those with mild to moderate cognitive impairment. Materials and methods: A casecontrol study in patients over 55- years with cognitive impairment, obtained by the MMSE® and MoCA® screening scales. A total of 191 patients, 102 patients with cognitive impairment (cases) and 89 healthy ones (controls) participated in the study. Blood samples were collected to obtain serum, with the determination of BDNF concentrations. For differences in BDNF concentrations, a one-way analysis of variance was used. The significance level of p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2667-0496 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2667049624000140; https://doaj.org/toc/2667-0496 |
| DOI: | 10.1016/j.neurop.2024.100158 |
| Access URL: | https://doaj.org/article/f80fb5d114fc42a4bcce6ebe47ad1a4a |
| Accession Number: | edsdoj.f80fb5d114fc42a4bcce6ebe47ad1a4a |
| Database: | Directory of Open Access Journals |
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