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Relationship between brain-derived neurotrophic factor and mild to moderate cognitive impairment in the older Mexican population

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Názov: Relationship between brain-derived neurotrophic factor and mild to moderate cognitive impairment in the older Mexican population
Autori: E. Rico-Fernández, C.A. Reyes-Hernandez, M.P. Rico-Fernández, F.J. García-Alvarado, H.A. Delgado-Aguirre
Zdroj: Neurology Perspectives, Vol 4, Iss 3, Pp 100158- (2024)
Informácie o vydavateľovi: Elsevier, 2024.
Rok vydania: 2024
Zbierka: LCC:Neurology. Diseases of the nervous system
Predmety: Deterioro cognitivo, Factor neurotrófico derivado del cerebro BDNF, Neurology. Diseases of the nervous system, RC346-429
Popis: Background: Mild–moderate cognitive impairment is a frequent pathology in the adult population. It is important to explore early expression biomarkers that contribute to early detection and benefit the prognostic outlook. Brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, neuronal survival, and differentiation, and even a critical molecular target for drug development in neurological disorders. It is crucial to carry out studies in the early stages that better clarify the landscape of BDNF. Objective: To compare the serum levels of BDNF in healthy adult patients and those with mild to moderate cognitive impairment. Materials and methods: A casecontrol study in patients over 55- years with cognitive impairment, obtained by the MMSE® and MoCA® screening scales. A total of 191 patients, 102 patients with cognitive impairment (cases) and 89 healthy ones (controls) participated in the study. Blood samples were collected to obtain serum, with the determination of BDNF concentrations. For differences in BDNF concentrations, a one-way analysis of variance was used. The significance level of p
Druh dokumentu: article
Popis súboru: electronic resource
Jazyk: English
ISSN: 2667-0496
Relation: http://www.sciencedirect.com/science/article/pii/S2667049624000140; https://doaj.org/toc/2667-0496
DOI: 10.1016/j.neurop.2024.100158
Prístupová URL adresa: https://doaj.org/article/f80fb5d114fc42a4bcce6ebe47ad1a4a
Prístupové číslo: edsdoj.f80fb5d114fc42a4bcce6ebe47ad1a4a
Databáza: Directory of Open Access Journals
Popis
Abstrakt:Background: Mild–moderate cognitive impairment is a frequent pathology in the adult population. It is important to explore early expression biomarkers that contribute to early detection and benefit the prognostic outlook. Brain-derived neurotrophic factor (BDNF) is an essential regulator of synaptic plasticity, neuronal survival, and differentiation, and even a critical molecular target for drug development in neurological disorders. It is crucial to carry out studies in the early stages that better clarify the landscape of BDNF. Objective: To compare the serum levels of BDNF in healthy adult patients and those with mild to moderate cognitive impairment. Materials and methods: A casecontrol study in patients over 55- years with cognitive impairment, obtained by the MMSE® and MoCA® screening scales. A total of 191 patients, 102 patients with cognitive impairment (cases) and 89 healthy ones (controls) participated in the study. Blood samples were collected to obtain serum, with the determination of BDNF concentrations. For differences in BDNF concentrations, a one-way analysis of variance was used. The significance level of p
ISSN:26670496
DOI:10.1016/j.neurop.2024.100158