The immunomodulatory role of clove and cinnamon extracts on Klebsiella pneumoniae infected rats
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| Název: | The immunomodulatory role of clove and cinnamon extracts on Klebsiella pneumoniae infected rats |
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| Autoři: | Z. E. Sadeq, I. J. Lafta, F. M. K. AL-Rekabi, R. A. Faraj |
| Zdroj: | Bulgarian Journal of Veterinary Medicine, Vol 28, Iss 4, Pp 702-716 (2025) |
| Informace o vydavateli: | Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria, 2025. |
| Rok vydání: | 2025 |
| Sbírka: | LCC:Veterinary medicine |
| Témata: | cinnamon, clove, complete blood counts, il-4 and ifn-γ, klebsiella pneumoniae, Veterinary medicine, SF600-1100 |
| Popis: | This study aimed to investigate the ability of clove and cinnamon extracts to make pathogenic mul-tidrug-resistant (MDR) Klebsiella pneumoniae more sensitive to the host’s immune system and thereby interrupt the bacterial infection process in the rat model. Therefore, 60 Wistar male rats were used in this study. The phytochemical constituents of the plant extract were analysed using the gas chromatography-mass spectrometry (GC-MS) technique. Then, the capability of the plant extracts, as prophylactic and treatment, against K. pneumoniae in rats was studied by estimating the complete blood counts (CBCs) and the serum concentrations of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) before and after the treatment. The results showed that the main phytoconstituent present in the aqueous ethanolic extract of cinnamon was cinnamaldehyde, and eugenol for clove. Concerning the haematological pa-rameter, significant alterations in white blood cell counts, lymphocytes %, monocytes %, granulocytes %, and plateletcrit % were observed in the blood of animals. Increased IL-4 and IFN-γ levels occurred following the administration of cinnamon and clove, and that increase was dose-dependent. To con-clude, clove and cinnamon ethanolic extracts exerted potent immunomodulatory effects against K. pneumoniae. The study recommends further exploration of these plant extracts separately or in combina-tion to develop alternative therapies against MDR K. pneumoniae infections. |
| Druh dokumentu: | article |
| Popis souboru: | electronic resource |
| Jazyk: | English |
| ISSN: | 1311-1477 1313-3543 |
| Relation: | https://doaj.org/toc/1311-1477; https://doaj.org/toc/1313-3543 |
| DOI: | 10.15547/bjvm.2024-0104 |
| Přístupová URL adresa: | https://doaj.org/article/f8009646bfc140ce927b8d49b87907fa |
| Přístupové číslo: | edsdoj.f8009646bfc140ce927b8d49b87907fa |
| Databáze: | Directory of Open Access Journals |
| Abstrakt: | This study aimed to investigate the ability of clove and cinnamon extracts to make pathogenic mul-tidrug-resistant (MDR) Klebsiella pneumoniae more sensitive to the host’s immune system and thereby interrupt the bacterial infection process in the rat model. Therefore, 60 Wistar male rats were used in this study. The phytochemical constituents of the plant extract were analysed using the gas chromatography-mass spectrometry (GC-MS) technique. Then, the capability of the plant extracts, as prophylactic and treatment, against K. pneumoniae in rats was studied by estimating the complete blood counts (CBCs) and the serum concentrations of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) before and after the treatment. The results showed that the main phytoconstituent present in the aqueous ethanolic extract of cinnamon was cinnamaldehyde, and eugenol for clove. Concerning the haematological pa-rameter, significant alterations in white blood cell counts, lymphocytes %, monocytes %, granulocytes %, and plateletcrit % were observed in the blood of animals. Increased IL-4 and IFN-γ levels occurred following the administration of cinnamon and clove, and that increase was dose-dependent. To con-clude, clove and cinnamon ethanolic extracts exerted potent immunomodulatory effects against K. pneumoniae. The study recommends further exploration of these plant extracts separately or in combina-tion to develop alternative therapies against MDR K. pneumoniae infections. |
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| ISSN: | 13111477 13133543 |
| DOI: | 10.15547/bjvm.2024-0104 |