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Association of Neutrophil‐to‐Lymphocyte Ratio With All‐Cause and Cardiovascular Mortality Among Individuals With Depression: A Large‐Scale Cohort Study

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Title: Association of Neutrophil‐to‐Lymphocyte Ratio With All‐Cause and Cardiovascular Mortality Among Individuals With Depression: A Large‐Scale Cohort Study
Authors: Yue Chai, Guoxin Wang, Shumin Zhu, Congzhen Wei, Runsen Du, Zining Liu, Shuo Zhao, Li Yang, Yulan Geng
Source: Brain and Behavior, Vol 15, Iss 10, Pp n/a-n/a (2025)
Publisher Information: Wiley, 2025.
Publication Year: 2025
Collection: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Subject Terms: all‐cause mortality, cardiovascular diseases mortality, depression, National Health and Nutrition Examination Survey (NHANES), neutrophil‐lymphocyte ratio (NLR), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Description: ABSTRACT Background The relationship between mortality in depressed patients and the neutrophil‐to‐lymphocyte ratio (NLR) is not well‐documented. Methods This cohort study, involving 8749 individuals diagnosed with depression, was derived from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Data on mortality were obtained by linking the cohort database to the National Death Index, with updates available as of December 31, 2019. Various analytical techniques, including Cox proportional hazards models, restricted cubic splines, Kaplan‐Meier curves, and subgroup and sensitivity analyses, were employed. Results During an average follow‐up period of 84 months, 1023 participants (11.7%) died, with 271 of these deaths attributed to cardiovascular diseases (CVD). Our analysis demonstrated a positive connection among the NLR as well as mortality risk in all participants. In contrast to participants in the low NLR category (NLR ≤ 3.06), individuals belonging to the high NLR category (NLR > 3.06) exhibited a 64% increased risk of all‐cause mortality (hazard ratio [HR] 1.63, 95% confidence interval [CI] 1.36–1.95) and a 144% elevated risk of mortality due to CVD (HR 2.44, 95%CI 1.77–3.36) after multivariate adjustment. The interactions and data stratification supported the credibility of our results. Importantly, we discovered notable interactions within subgroups that were differentiated by age and diabetes. Conclusions Elevated levels of the NLR are linked to a heightened risk of mortality from all causes, including CVD, among adults suffering from depression. This correlation is particularly pronounced in younger populations and in individuals who have diabetes.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2162-3279
Relation: https://doaj.org/toc/2162-3279
DOI: 10.1002/brb3.70983
Access URL: https://doaj.org/article/db98fa303be44cd2a2de0d6e253fd2e4
Accession Number: edsdoj.b98fa303be44cd2a2de0d6e253fd2e4
Database: Directory of Open Access Journals
Description
Abstract:ABSTRACT Background The relationship between mortality in depressed patients and the neutrophil‐to‐lymphocyte ratio (NLR) is not well‐documented. Methods This cohort study, involving 8749 individuals diagnosed with depression, was derived from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Data on mortality were obtained by linking the cohort database to the National Death Index, with updates available as of December 31, 2019. Various analytical techniques, including Cox proportional hazards models, restricted cubic splines, Kaplan‐Meier curves, and subgroup and sensitivity analyses, were employed. Results During an average follow‐up period of 84 months, 1023 participants (11.7%) died, with 271 of these deaths attributed to cardiovascular diseases (CVD). Our analysis demonstrated a positive connection among the NLR as well as mortality risk in all participants. In contrast to participants in the low NLR category (NLR ≤ 3.06), individuals belonging to the high NLR category (NLR > 3.06) exhibited a 64% increased risk of all‐cause mortality (hazard ratio [HR] 1.63, 95% confidence interval [CI] 1.36–1.95) and a 144% elevated risk of mortality due to CVD (HR 2.44, 95%CI 1.77–3.36) after multivariate adjustment. The interactions and data stratification supported the credibility of our results. Importantly, we discovered notable interactions within subgroups that were differentiated by age and diabetes. Conclusions Elevated levels of the NLR are linked to a heightened risk of mortality from all causes, including CVD, among adults suffering from depression. This correlation is particularly pronounced in younger populations and in individuals who have diabetes.
ISSN:21623279
DOI:10.1002/brb3.70983