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Surgical Management of Rectal Gastrointestinal Stromal Tumours: Our Local Experience

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Bibliographic Details
Title: Surgical Management of Rectal Gastrointestinal Stromal Tumours: Our Local Experience
Authors: Yen Min Madeline Chee, Emile John Tan Kwong Wei
Source: World Journal of Colorectal Surgery, Vol 14, Iss 3, Pp 99-102 (2025)
Publisher Information: Wolters Kluwer Medknow Publications, 2025.
Publication Year: 2025
Collection: LCC:Surgery
Subject Terms: colorectal surgery, local resection, radical resection, rectal gastrointestinal stromal tumour, Surgery, RD1-811
Description: Background: Surgical management of rectal gastrointestinal stromal tumours (GISTs) varies widely. Options include local excision (LE) or radical surgery (RS). Objectives: To describe our experience with the surgical management of rectal GISTs and compare the feasibility, safety, and outcomes of LE versus RS. Design: From January 2014 to October 2024, all patients diagnosed with rectal GIST who underwent surgical management were included. Settings: Singapore institution. Patient and Methods: Retrospective review. Main Outcome Measures: Effects of imatinib, perioperative, and oncological outcomes were compared between upfront surgery and surgery after neoadjuvant therapy, as well as between LE and RS. Sample Size: 11. Results: Five and six patients underwent LE and RS, respectively. Median tumor size in the LE group was smaller than in the RS group (35 vs 67 mm, P = .165). Median age in the LE and RS groups was 58 and 69 years, respectively (P = .358). R0 resection was achieved in 60% and 83.3% of patients in the LE and RS groups, respectively (P = .667). Adjuvant imatinib was received by 40% in the LE group and 83.3% in the RS group (P = .197). Median follow-up was 42 and 68 months in the LE and RS groups, respectively (P = .464). All patients were alive at follow-up, but one patient in each group experienced local recurrence. Operative time and postoperative length of stay were significantly longer for patients undergoing RS. No postoperative complications or deaths occurred. Conclusion: LE may be a preferred surgical option for selected rectal GISTs as it preserves anal sphincter function and is associated with significantly shorter operative times and postoperative length of stay compared to RS, with comparable oncological outcomes. Limitations: Small sample size; retrospective nature. Conflict of Interest: None.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1941-8213
Relation: https://journals.lww.com/10.4103/wjcs.wjcs_14_25; https://doaj.org/toc/1941-8213
DOI: 10.4103/wjcs.wjcs_14_25
Access URL: https://doaj.org/article/b6b07255071744df9e68e59a37bfa9a7
Accession Number: edsdoj.b6b07255071744df9e68e59a37bfa9a7
Database: Directory of Open Access Journals
Description
Abstract:Background: Surgical management of rectal gastrointestinal stromal tumours (GISTs) varies widely. Options include local excision (LE) or radical surgery (RS). Objectives: To describe our experience with the surgical management of rectal GISTs and compare the feasibility, safety, and outcomes of LE versus RS. Design: From January 2014 to October 2024, all patients diagnosed with rectal GIST who underwent surgical management were included. Settings: Singapore institution. Patient and Methods: Retrospective review. Main Outcome Measures: Effects of imatinib, perioperative, and oncological outcomes were compared between upfront surgery and surgery after neoadjuvant therapy, as well as between LE and RS. Sample Size: 11. Results: Five and six patients underwent LE and RS, respectively. Median tumor size in the LE group was smaller than in the RS group (35 vs 67 mm, P = .165). Median age in the LE and RS groups was 58 and 69 years, respectively (P = .358). R0 resection was achieved in 60% and 83.3% of patients in the LE and RS groups, respectively (P = .667). Adjuvant imatinib was received by 40% in the LE group and 83.3% in the RS group (P = .197). Median follow-up was 42 and 68 months in the LE and RS groups, respectively (P = .464). All patients were alive at follow-up, but one patient in each group experienced local recurrence. Operative time and postoperative length of stay were significantly longer for patients undergoing RS. No postoperative complications or deaths occurred. Conclusion: LE may be a preferred surgical option for selected rectal GISTs as it preserves anal sphincter function and is associated with significantly shorter operative times and postoperative length of stay compared to RS, with comparable oncological outcomes. Limitations: Small sample size; retrospective nature. Conflict of Interest: None.
ISSN:19418213
DOI:10.4103/wjcs.wjcs_14_25